search button

The clinical implications of glutathione S-transferase-pi expression in lung cancer

  • Authors:
    • S Fujino
    • M Oka
    • A Sakamoto
    • M Fukuda
    • H Takatani
    • K Terashi
    • F Narasaki
    • K Ikeda
    • Y Inoue
    • A Kinoshita
    • H Soda
    • T Kanda
    • S Kohno

  • View Affiliations

  • Published online on: March 1, 1997     https://doi.org/10.3892/or.4.2.311
  • Pages: 311-313
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We performed immunohistochemical staining of glutathione S-transferase-pi (GST-pi) in 97 lung cancer specimens. In untreated patients, 86% (48/56) of NSCLC and none (0/8) of SCLC stained for GST-pi, and all squamous cell carcinomas were positive (28/28). The proportion of positive NSCLC with preoperative chemotherapy was similar to that of the untreated NSCLC, but the proportion of treated SCLC positive for GST-pi (14/18) was significantly higher than untreated tumors. GST-pi in NSCLC may be a tumor marker rather than being involved in drug resistance, and GST-pi-induction by chemotherapy may relate to acquired resistance in SCLC.

Related Articles

Journal Cover

March 1997
Volume 4 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Fujino S, Oka M, Sakamoto A, Fukuda M, Takatani H, Terashi K, Narasaki F, Ikeda K, Inoue Y, Kinoshita A, Kinoshita A, et al: The clinical implications of glutathione S-transferase-pi expression in lung cancer. Oncol Rep 4: 311-313, 1997.
APA
Fujino, S., Oka, M., Sakamoto, A., Fukuda, M., Takatani, H., Terashi, K. ... Kohno, S. (1997). The clinical implications of glutathione S-transferase-pi expression in lung cancer. Oncology Reports, 4, 311-313. https://doi.org/10.3892/or.4.2.311
MLA
Fujino, S., Oka, M., Sakamoto, A., Fukuda, M., Takatani, H., Terashi, K., Narasaki, F., Ikeda, K., Inoue, Y., Kinoshita, A., Soda, H., Kanda, T., Kohno, S."The clinical implications of glutathione S-transferase-pi expression in lung cancer". Oncology Reports 4.2 (1997): 311-313.
Chicago
Fujino, S., Oka, M., Sakamoto, A., Fukuda, M., Takatani, H., Terashi, K., Narasaki, F., Ikeda, K., Inoue, Y., Kinoshita, A., Soda, H., Kanda, T., Kohno, S."The clinical implications of glutathione S-transferase-pi expression in lung cancer". Oncology Reports 4, no. 2 (1997): 311-313. https://doi.org/10.3892/or.4.2.311