Oligosaccharide Le(a)-Le(x): a cell surface marker for carcinomas derived from embryonic endoderm.

Stranahan,P L; LaRoe,J; McCombs,R; Rahim,I; Kuhn,C W; Pettijohn,D E

doi:10.3892/or.5.1.235

Oligosaccharide Le(a)-Le(x): a cell surface marker for carcinomas derived from embryonic endoderm.

Authors:
- P L Stranahan
- J LaRoe
- R McCombs
- I Rahim
- C W Kuhn
- D E Pettijohn
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Affiliations: University of Colorado Cancer Center, Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
Published online on: January 1, 1998 https://doi.org/10.3892/or.5.1.235
Pages: 235-244

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Abstract

An immunohistochemical evaluation of Le(a)-Le(x) expression by adenocarcinomas of the biliary tree, pancreas, colon and stomach was undertaken as examples of epithelial tumors derived from embryonic endoderm. This complements previous studies showing that Lea-Lex was present on the cell surface of non-small cell lung carcinomas, some non-lung carcinomas, and is a prognostic marker for squamous cell lung carcinomas. All of the tumor specimen evaluated were positive and no expression of Le(a)-Le(x) was detected in derivatives of neural, connective or muscle tissues. These findings indicate that it could be informative to examine the biological significance of Le(a)-Le(x) not only in carcinogenesis but during embryogenesis, as well.