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Induction of apoptosis in human stomach cancer cells by green tea catechins.

  • Authors:
    • H Hibasami
    • T Komiya
    • Y Achiwa
    • K Ohnishi
    • T Kojima
    • K Nakanishi
    • K Akashi
    • Y Hara

  • View Affiliations

  • Published online on: March 1, 1998     https://doi.org/10.3892/or.5.2.527
  • Pages: 527-536
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Abstract

The exposure of human stomach cancer KATO III cells to green tea catechin extract and epigallocatechin gallate (EGCG), a main component of the extract led to both growth inhibition and the induction of programmed cell death (apoptosis). Morphological changes showing apoptotic body were observed in the cells treated with green tea catechin extract and EGCG. The fragmentation of DNA to oligonucleosomal-sized fragments, characteristic of apoptosis was determined to be concentration- and time-dependent. These data suggest that drinking of green tea in large amounts is recommended possibly to protect humans from stomach cancer.

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Mar-Apr 1998
Volume 5 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Hibasami H, Komiya T, Achiwa Y, Ohnishi K, Kojima T, Nakanishi K, Akashi K and Hara Y: Induction of apoptosis in human stomach cancer cells by green tea catechins.. Oncol Rep 5: 527-536, 1998.
APA
Hibasami, H., Komiya, T., Achiwa, Y., Ohnishi, K., Kojima, T., Nakanishi, K. ... Hara, Y. (1998). Induction of apoptosis in human stomach cancer cells by green tea catechins.. Oncology Reports, 5, 527-536. https://doi.org/10.3892/or.5.2.527
MLA
Hibasami, H., Komiya, T., Achiwa, Y., Ohnishi, K., Kojima, T., Nakanishi, K., Akashi, K., Hara, Y."Induction of apoptosis in human stomach cancer cells by green tea catechins.". Oncology Reports 5.2 (1998): 527-536.
Chicago
Hibasami, H., Komiya, T., Achiwa, Y., Ohnishi, K., Kojima, T., Nakanishi, K., Akashi, K., Hara, Y."Induction of apoptosis in human stomach cancer cells by green tea catechins.". Oncology Reports 5, no. 2 (1998): 527-536. https://doi.org/10.3892/or.5.2.527