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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Sep-Oct 1998 Volume 5 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Sep-Oct 1998 Volume 5 Issue 5

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Article

E-cadherin but not N-cadherin expression is correlated with the intracellular distribution of catenins in human hepatocellular carcinomas.

  • Authors:
    • K Nuruki
    • H Toyoyama
    • S Ueno
    • M Hamanoue
    • G Tanabe
    • T Aikou
    • M Ozawa

  • View Affiliations / Copyright

    Affiliations: Departments of Biochemistry and Surgery, Faculty of Medicine, Kagoshima University, Kagoshima 890-8520, Japan.
  • Pages: 1109-1123
    |
    Published online on: September 1, 1998
       https://doi.org/10.3892/or.5.5.1109
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Abstract

Cadherins are Ca2+-dependent cell-cell adhesion molecules, and are involved in the formation and maintenance of the histo-architecture. Using a combination of biochemical and immunohistochemical methods, we analyzed the expression of the cadherin-catenin complex in 34 human hepatocellular carcinomas. Unexpectedly, we found the expression of N (neural)-cadherin in normal hepatocytes and all hepatocellular carcinomas examined. In 18 cases, the decreased expression of E (epithelial)-cadherin was observed. Among them, the decreased expression of alpha-catenin and gamma-catenin (plakoglobin) was also observed in 9 and 6 cases, respectively. Thus the decreased expression of alpha-catenin and gamma-catenin was apparently preceded by the decreased expression of E-cadherin. The decreased expression of beta-catenin was not observed in any of the cases analyzed. beta-Catenin was found to accumulate in the cytoplasm of hepatocellular carcinomas with the decreased expression of E-cadherin, despite the presence of N-cadherin at the cell-cell contacts. These results suggest a pivotal role of E-cadherin in the intracellular distribution of catenins in hepatocellular carcinomas.

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Copy and paste a formatted citation
Spandidos Publications style
Nuruki K, Toyoyama H, Ueno S, Hamanoue M, Tanabe G, Aikou T and Ozawa M: E-cadherin but not N-cadherin expression is correlated with the intracellular distribution of catenins in human hepatocellular carcinomas.. Oncol Rep 5: 1109-1123, 1998.
APA
Nuruki, K., Toyoyama, H., Ueno, S., Hamanoue, M., Tanabe, G., Aikou, T., & Ozawa, M. (1998). E-cadherin but not N-cadherin expression is correlated with the intracellular distribution of catenins in human hepatocellular carcinomas.. Oncology Reports, 5, 1109-1123. https://doi.org/10.3892/or.5.5.1109
MLA
Nuruki, K., Toyoyama, H., Ueno, S., Hamanoue, M., Tanabe, G., Aikou, T., Ozawa, M."E-cadherin but not N-cadherin expression is correlated with the intracellular distribution of catenins in human hepatocellular carcinomas.". Oncology Reports 5.5 (1998): 1109-1123.
Chicago
Nuruki, K., Toyoyama, H., Ueno, S., Hamanoue, M., Tanabe, G., Aikou, T., Ozawa, M."E-cadherin but not N-cadherin expression is correlated with the intracellular distribution of catenins in human hepatocellular carcinomas.". Oncology Reports 5, no. 5 (1998): 1109-1123. https://doi.org/10.3892/or.5.5.1109
Copy and paste a formatted citation
x
Spandidos Publications style
Nuruki K, Toyoyama H, Ueno S, Hamanoue M, Tanabe G, Aikou T and Ozawa M: E-cadherin but not N-cadherin expression is correlated with the intracellular distribution of catenins in human hepatocellular carcinomas.. Oncol Rep 5: 1109-1123, 1998.
APA
Nuruki, K., Toyoyama, H., Ueno, S., Hamanoue, M., Tanabe, G., Aikou, T., & Ozawa, M. (1998). E-cadherin but not N-cadherin expression is correlated with the intracellular distribution of catenins in human hepatocellular carcinomas.. Oncology Reports, 5, 1109-1123. https://doi.org/10.3892/or.5.5.1109
MLA
Nuruki, K., Toyoyama, H., Ueno, S., Hamanoue, M., Tanabe, G., Aikou, T., Ozawa, M."E-cadherin but not N-cadherin expression is correlated with the intracellular distribution of catenins in human hepatocellular carcinomas.". Oncology Reports 5.5 (1998): 1109-1123.
Chicago
Nuruki, K., Toyoyama, H., Ueno, S., Hamanoue, M., Tanabe, G., Aikou, T., Ozawa, M."E-cadherin but not N-cadherin expression is correlated with the intracellular distribution of catenins in human hepatocellular carcinomas.". Oncology Reports 5, no. 5 (1998): 1109-1123. https://doi.org/10.3892/or.5.5.1109
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