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Expression of proliferating cell nuclear antigen in follicular thyroid tumors: correlation with clinicopathological findings.

  • Authors:
    • V Vassko
    • S Garcia
    • J F Henry
    • C De Micco

  • View Affiliations

  • Published online on: March 1, 1999     https://doi.org/10.3892/or.6.2.359
  • Pages: 359-423
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Abstract

The purpose of this study was to correlate proliferating cell nuclear antigen (PCNA) immunostaining with clinicopathological findings in 60 follicular thyroid tumors. Mean proliferative index (PI) was significantly higher for carcinoma (73%) than microfollicular adenoma (19.6%) (p<0.0001). For atypical and oncocytic adenomas, intermediate PI values (64% and 50%) correlated with size and cytological atypia but not with sex and age. PCNA immunostaining is of limited value for differential diagnosis of malignant and atypical tumors but could be useful for identification of actively growing atypical follicular thyroid nodules on fine needle aspiration biopsies.

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Mar-Apr 1999
Volume 6 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Vassko V, Garcia S, Henry J and De Micco C: Expression of proliferating cell nuclear antigen in follicular thyroid tumors: correlation with clinicopathological findings.. Oncol Rep 6: 359-423, 1999.
APA
Vassko, V., Garcia, S., Henry, J., & De Micco, C. (1999). Expression of proliferating cell nuclear antigen in follicular thyroid tumors: correlation with clinicopathological findings.. Oncology Reports, 6, 359-423. https://doi.org/10.3892/or.6.2.359
MLA
Vassko, V., Garcia, S., Henry, J., De Micco, C."Expression of proliferating cell nuclear antigen in follicular thyroid tumors: correlation with clinicopathological findings.". Oncology Reports 6.2 (1999): 359-423.
Chicago
Vassko, V., Garcia, S., Henry, J., De Micco, C."Expression of proliferating cell nuclear antigen in follicular thyroid tumors: correlation with clinicopathological findings.". Oncology Reports 6, no. 2 (1999): 359-423. https://doi.org/10.3892/or.6.2.359