search button

The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).

  • Authors:
    • D E Gomez
    • G Skilton
    • D F Alonso
    • M G Kazanietz

  • View Affiliations

  • Published online on: November 1, 1999     https://doi.org/10.3892/or.6.6.1363
  • Pages: 1363-1433
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Phorbol ester tumor promoters activate protein kinase C (PKC) isozymes and novel non-kinase receptors, suggesting a high degree of complexity in the signaling mechanisms of tumorigenesis. Many studies have shown that PKC isozymes contribute to the progression of malignant phenotype. We review the emerging understanding of the roles of PKC isozymes in the three sequential cellular processes of tumor invasion and metastasis: attachment to extracellular matrix or basement membrane components, matrix degradation by proteolytic enzymes, and migration through the digested matrix. In addition, we discuss the potential role of chimaerins, novel non-kinase phorbol ester receptors, in carcinogenesis.

Related Articles

Journal Cover

Nov-Dec 1999
Volume 6 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Gomez D, Skilton G, Alonso D and Kazanietz M: The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).. Oncol Rep 6: 1363-1433, 1999.
APA
Gomez, D., Skilton, G., Alonso, D., & Kazanietz, M. (1999). The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).. Oncology Reports, 6, 1363-1433. https://doi.org/10.3892/or.6.6.1363
MLA
Gomez, D., Skilton, G., Alonso, D., Kazanietz, M."The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).". Oncology Reports 6.6 (1999): 1363-1433.
Chicago
Gomez, D., Skilton, G., Alonso, D., Kazanietz, M."The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).". Oncology Reports 6, no. 6 (1999): 1363-1433. https://doi.org/10.3892/or.6.6.1363