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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Nov-Dec 1999 Volume 6 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Nov-Dec 1999 Volume 6 Issue 6

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Article

The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).

  • Authors:
    • D E Gomez
    • G Skilton
    • D F Alonso
    • M G Kazanietz
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Oncology, Department of Science and Technology, Quilmes National University, 1876 Buenos Aires, Argentina.
  • Pages: 1363-1433
    |
    Published online on: November 1, 1999
       https://doi.org/10.3892/or.6.6.1363
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Abstract

Phorbol ester tumor promoters activate protein kinase C (PKC) isozymes and novel non-kinase receptors, suggesting a high degree of complexity in the signaling mechanisms of tumorigenesis. Many studies have shown that PKC isozymes contribute to the progression of malignant phenotype. We review the emerging understanding of the roles of PKC isozymes in the three sequential cellular processes of tumor invasion and metastasis: attachment to extracellular matrix or basement membrane components, matrix degradation by proteolytic enzymes, and migration through the digested matrix. In addition, we discuss the potential role of chimaerins, novel non-kinase phorbol ester receptors, in carcinogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Gomez D, Skilton G, Alonso D and Kazanietz M: The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).. Oncol Rep 6: 1363-1433, 1999.
APA
Gomez, D., Skilton, G., Alonso, D., & Kazanietz, M. (1999). The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).. Oncology Reports, 6, 1363-1433. https://doi.org/10.3892/or.6.6.1363
MLA
Gomez, D., Skilton, G., Alonso, D., Kazanietz, M."The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).". Oncology Reports 6.6 (1999): 1363-1433.
Chicago
Gomez, D., Skilton, G., Alonso, D., Kazanietz, M."The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).". Oncology Reports 6, no. 6 (1999): 1363-1433. https://doi.org/10.3892/or.6.6.1363
Copy and paste a formatted citation
x
Spandidos Publications style
Gomez D, Skilton G, Alonso D and Kazanietz M: The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).. Oncol Rep 6: 1363-1433, 1999.
APA
Gomez, D., Skilton, G., Alonso, D., & Kazanietz, M. (1999). The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).. Oncology Reports, 6, 1363-1433. https://doi.org/10.3892/or.6.6.1363
MLA
Gomez, D., Skilton, G., Alonso, D., Kazanietz, M."The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).". Oncology Reports 6.6 (1999): 1363-1433.
Chicago
Gomez, D., Skilton, G., Alonso, D., Kazanietz, M."The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).". Oncology Reports 6, no. 6 (1999): 1363-1433. https://doi.org/10.3892/or.6.6.1363
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