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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Nov-Dec 1999 Volume 6 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Nov-Dec 1999 Volume 6 Issue 6

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Article

Overexpression of CXC-chemokines and CXC-chemokine receptor type II constitute an autocrine growth mechanism in the epidermoid carcinoma cells KB and A431.

  • Authors:
    • B Metzner
    • C Hofmann
    • C Heinemann
    • U Zimpfer
    • I Schraufstätter
    • E Schöpf
    • J Norgauer

  • View Affiliations / Copyright

    Affiliations: Clinic of Dermatology, Divisions of Experimental and Clinical Dermatology, University of Freiburg, Freiburg, Germany.
  • Pages: 1405-1415
    |
    Published online on: November 1, 1999
       https://doi.org/10.3892/or.6.6.1405
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Abstract

The CXC-chemokines Groalpha and interleukin-8 (IL-8) are well characterized growth factors for melanoma cells. Here the constitutive expression of Groalpha, IL-8 and their receptors (CXCR1 and CXCR2) as well as their functional involvement in the proliferation response were analyzed in normal keratinocytes and epidermoid carcinoma cell lines A431 and KB. Flow cytometric measurements, ELISA and semi-quantitative RT-PCR revealed low constitutive protein secretion and mRNA expression of both CXC-chemokines as well as CXCR1 and 2 in normal keratinocytes, whereas significant higher levels of CXC-chemokines and CXCR2 were deteced in epidermoid carcinoma cells. Proliferation of epidermoid carcinoma cells could be induced by CXC-chemokines and constitutive proliferation could be inhibited by neutralizing antibodies against CXC-chemokines and CXCR2. These studies indicate that constitutive Groalpha, IL-8 and CXCR2 protein expression enable an autocrine growth mechanism in epidermoid carcinoma cells.

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Copy and paste a formatted citation
Spandidos Publications style
Metzner B, Hofmann C, Heinemann C, Zimpfer U, Schraufstätter I, Schöpf E and Norgauer J: Overexpression of CXC-chemokines and CXC-chemokine receptor type II constitute an autocrine growth mechanism in the epidermoid carcinoma cells KB and A431.. Oncol Rep 6: 1405-1415, 1999.
APA
Metzner, B., Hofmann, C., Heinemann, C., Zimpfer, U., Schraufstätter, I., Schöpf, E., & Norgauer, J. (1999). Overexpression of CXC-chemokines and CXC-chemokine receptor type II constitute an autocrine growth mechanism in the epidermoid carcinoma cells KB and A431.. Oncology Reports, 6, 1405-1415. https://doi.org/10.3892/or.6.6.1405
MLA
Metzner, B., Hofmann, C., Heinemann, C., Zimpfer, U., Schraufstätter, I., Schöpf, E., Norgauer, J."Overexpression of CXC-chemokines and CXC-chemokine receptor type II constitute an autocrine growth mechanism in the epidermoid carcinoma cells KB and A431.". Oncology Reports 6.6 (1999): 1405-1415.
Chicago
Metzner, B., Hofmann, C., Heinemann, C., Zimpfer, U., Schraufstätter, I., Schöpf, E., Norgauer, J."Overexpression of CXC-chemokines and CXC-chemokine receptor type II constitute an autocrine growth mechanism in the epidermoid carcinoma cells KB and A431.". Oncology Reports 6, no. 6 (1999): 1405-1415. https://doi.org/10.3892/or.6.6.1405
Copy and paste a formatted citation
x
Spandidos Publications style
Metzner B, Hofmann C, Heinemann C, Zimpfer U, Schraufstätter I, Schöpf E and Norgauer J: Overexpression of CXC-chemokines and CXC-chemokine receptor type II constitute an autocrine growth mechanism in the epidermoid carcinoma cells KB and A431.. Oncol Rep 6: 1405-1415, 1999.
APA
Metzner, B., Hofmann, C., Heinemann, C., Zimpfer, U., Schraufstätter, I., Schöpf, E., & Norgauer, J. (1999). Overexpression of CXC-chemokines and CXC-chemokine receptor type II constitute an autocrine growth mechanism in the epidermoid carcinoma cells KB and A431.. Oncology Reports, 6, 1405-1415. https://doi.org/10.3892/or.6.6.1405
MLA
Metzner, B., Hofmann, C., Heinemann, C., Zimpfer, U., Schraufstätter, I., Schöpf, E., Norgauer, J."Overexpression of CXC-chemokines and CXC-chemokine receptor type II constitute an autocrine growth mechanism in the epidermoid carcinoma cells KB and A431.". Oncology Reports 6.6 (1999): 1405-1415.
Chicago
Metzner, B., Hofmann, C., Heinemann, C., Zimpfer, U., Schraufstätter, I., Schöpf, E., Norgauer, J."Overexpression of CXC-chemokines and CXC-chemokine receptor type II constitute an autocrine growth mechanism in the epidermoid carcinoma cells KB and A431.". Oncology Reports 6, no. 6 (1999): 1405-1415. https://doi.org/10.3892/or.6.6.1405
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