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Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.

  • Authors:
    • K Dolan
    • J Garde
    • S J Walker
    • R Sutton
    • J Gosney
    • J K Field

  • View Affiliations

  • Published online on: May 1, 2000     https://doi.org/10.3892/or.7.3.521
  • Pages: 521-529
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Abstract

Seventy malignant, premalignant and histologically normal biopsies from 7 oesophagogastrectomy specimens of adenocarcinomas of the lower oesophagus and gastroesophageal junction were analysed for loss of heterozygosity (LOH) at 9 known or putative gene loci. LOH was detected in 20 of 27 (74%) malignant biopsies, 4 of 7 (57%) biopsies of dysplasia, 2 of 12 (25%) biopsies of histologically normal oesophagus adjacent to adenocarcinoma, and in 2 of 14 (14%) biopsies of histologically normal stomach adjacent to adenocarcinoma. LOH at the VHL, APC, CDKN2 and DCC tumour suppressor and MSH3 mismatch repair gene loci can be detected in histologically normal tissue and in adjacent adenocarcinoma, and are potential markers of early neoplastic progression.

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May-Jun 2000
Volume 7 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 3.8
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Dolan K, Garde J, Walker S, Sutton R, Gosney J and Field J: Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.. Oncol Rep 7: 521-529, 2000.
APA
Dolan, K., Garde, J., Walker, S., Sutton, R., Gosney, J., & Field, J. (2000). Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.. Oncology Reports, 7, 521-529. https://doi.org/10.3892/or.7.3.521
MLA
Dolan, K., Garde, J., Walker, S., Sutton, R., Gosney, J., Field, J."Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.". Oncology Reports 7.3 (2000): 521-529.
Chicago
Dolan, K., Garde, J., Walker, S., Sutton, R., Gosney, J., Field, J."Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.". Oncology Reports 7, no. 3 (2000): 521-529. https://doi.org/10.3892/or.7.3.521