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Cdc6 expression as a marker of proliferative activity in brain tumors

  • Authors:
    • Seiji Ohta
    • Masayo Koide
    • Tsutomu Tokuyama
    • Naoki Yokota
    • Shigeru Nishizawa
    • Hiroki Namba

  • View Affiliations

  • Published online on: September 1, 2001     https://doi.org/10.3892/or.8.5.1063
  • Pages: 1063-1066
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Abstract

Antibodies against human proteins that regulate DNA replication such as Cdc6 and Mcm5 became available as a new marker of proliferation. We performed immunohistochemical analysis with MIB-1 and antibody against Cdc6 on 35 brain tumors, including tumors of neuroepithelial tissue, vestibular schwannomas, meningiomas, and pituitary adenomas. Median reactivity for MIB-1 was 8.8%, and that for Cdc6 was 55%. Reactivity in most brain tumors was significantly higher for Cdc6 than for MIB-1, but reactivity of Cdc6 was independent of tumor grade. Detection of Cdc6 expression might be useful for the estimation of proliferative activity in brain tumors.

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September-October 2001
Volume 8 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Ohta S, Koide M, Tokuyama T, Yokota N, Nishizawa S and Namba H: Cdc6 expression as a marker of proliferative activity in brain tumors. Oncol Rep 8: 1063-1066, 2001.
APA
Ohta, S., Koide, M., Tokuyama, T., Yokota, N., Nishizawa, S., & Namba, H. (2001). Cdc6 expression as a marker of proliferative activity in brain tumors. Oncology Reports, 8, 1063-1066. https://doi.org/10.3892/or.8.5.1063
MLA
Ohta, S., Koide, M., Tokuyama, T., Yokota, N., Nishizawa, S., Namba, H."Cdc6 expression as a marker of proliferative activity in brain tumors". Oncology Reports 8.5 (2001): 1063-1066.
Chicago
Ohta, S., Koide, M., Tokuyama, T., Yokota, N., Nishizawa, S., Namba, H."Cdc6 expression as a marker of proliferative activity in brain tumors". Oncology Reports 8, no. 5 (2001): 1063-1066. https://doi.org/10.3892/or.8.5.1063