Retinoic acid inhibits fibronectin and laminin synthesis and cell migration of human pleural mesothelioma in vitro

  • Authors:
    • Susanna Scarpa
    • Anna Giuffrida
    • Camilla Palumbo
    • Anna Coletti
    • Maria Grazia Cerrito
    • Fortunata Vasaturo
    • Paola Sinibaldi
    • Lucilla Simonelli
    • Antonio Procopio
    • Andrea Modesti
  • View Affiliations

  • Published online on: January 1, 2002     https://doi.org/10.3892/or.9.1.205
  • Pages: 205-209
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Abstract

The effects of retinoic acid (RA) on cell replication, fibronectin and laminin synthesis, integrin expression and haptotactic migration of three mesothelioma cell cultures of different histotype, one epithelioid, one fibromatous and one biphasic, were evaluated. Cell growth was not affected by RA, while RA treatment decreased the synthesis of fibronectin and laminin and inhibited the migration of all three mesotheliomas on substrates of fibronectin and laminin; on the contrary, the expression of some integrins was not significantly modified by RA. These data indicate that RA may lead to a decrease of mesothelioma cell local invasion; this can correlate with a modification induced by RA on mesothelioma tumor progression in vivo.

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January-February 2002
Volume 9 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Scarpa S, Giuffrida A, Palumbo C, Coletti A, Cerrito MG, Vasaturo F, Sinibaldi P, Simonelli L, Procopio A, Modesti A, Modesti A, et al: Retinoic acid inhibits fibronectin and laminin synthesis and cell migration of human pleural mesothelioma in vitro. Oncol Rep 9: 205-209, 2002.
APA
Scarpa, S., Giuffrida, A., Palumbo, C., Coletti, A., Cerrito, M.G., Vasaturo, F. ... Modesti, A. (2002). Retinoic acid inhibits fibronectin and laminin synthesis and cell migration of human pleural mesothelioma in vitro. Oncology Reports, 9, 205-209. https://doi.org/10.3892/or.9.1.205
MLA
Scarpa, S., Giuffrida, A., Palumbo, C., Coletti, A., Cerrito, M. G., Vasaturo, F., Sinibaldi, P., Simonelli, L., Procopio, A., Modesti, A."Retinoic acid inhibits fibronectin and laminin synthesis and cell migration of human pleural mesothelioma in vitro". Oncology Reports 9.1 (2002): 205-209.
Chicago
Scarpa, S., Giuffrida, A., Palumbo, C., Coletti, A., Cerrito, M. G., Vasaturo, F., Sinibaldi, P., Simonelli, L., Procopio, A., Modesti, A."Retinoic acid inhibits fibronectin and laminin synthesis and cell migration of human pleural mesothelioma in vitro". Oncology Reports 9, no. 1 (2002): 205-209. https://doi.org/10.3892/or.9.1.205