Potent antitumor effect of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine on peritoneal dissemination models of gastrointestinal cancers

  • Authors:
    • Shinji Miura
    • Yoshio Endo
    • Yuichi Yoshimura
    • Mikari Endo
    • Yutaka Yonemura
    • Takuma Sasaki
  • View Affiliations

  • Published online on: November 1, 2002     https://doi.org/10.3892/or.9.6.1319
  • Pages: 1319-1322
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Abstract

We investigated the antitumor activity of the nucleoside analog 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine (4__AMB__apos;-thio-FAC) in peritoneal dissemination models of gastrointestinal cancers. Oral administration of 4__AMB__apos;-thio-FAC showed a marked effect on the development of ascites and on the survival of nude mice implanted with the highly metastatic MKN-45-P gastric cancer cells into the peritoneal cavity. The toxic effect was observed at a dose of 15 mg/kg, however, no toxicity was observed at a dose of 10 mg/kg with excellent antitumor activity. We established another highly metastatic cell line HCT-15-P by serial intraperitoneal passage of the colon cancer cell line HCT-15. In the HCT-15-P model, 4__AMB__apos;-thio-FAC showed an inhibitory effect of peritoneal dissemination and an increase in the life span at a dose of 10 mg/kg. On the other hand, oral administration of 5-fluorouracil (5-FU) and 5__AMB__apos;-deoxy-5-fluorouridine (5__AMB__apos;-DFUR) did not show an increase in the life span of mice at a dose of 10 mg/kg. In conclusion, 4__AMB__apos;-thio-FAC is a promising therapeutic agent for use against peritoneal dissemination of gastrointestinal cancers.

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November-December 2002
Volume 9 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Miura S, Endo Y, Yoshimura Y, Endo M, Yonemura Y and Sasaki T: Potent antitumor effect of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine on peritoneal dissemination models of gastrointestinal cancers. Oncol Rep 9: 1319-1322, 2002.
APA
Miura, S., Endo, Y., Yoshimura, Y., Endo, M., Yonemura, Y., & Sasaki, T. (2002). Potent antitumor effect of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine on peritoneal dissemination models of gastrointestinal cancers. Oncology Reports, 9, 1319-1322. https://doi.org/10.3892/or.9.6.1319
MLA
Miura, S., Endo, Y., Yoshimura, Y., Endo, M., Yonemura, Y., Sasaki, T."Potent antitumor effect of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine on peritoneal dissemination models of gastrointestinal cancers". Oncology Reports 9.6 (2002): 1319-1322.
Chicago
Miura, S., Endo, Y., Yoshimura, Y., Endo, M., Yonemura, Y., Sasaki, T."Potent antitumor effect of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine on peritoneal dissemination models of gastrointestinal cancers". Oncology Reports 9, no. 6 (2002): 1319-1322. https://doi.org/10.3892/or.9.6.1319