search button

Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways

  • Authors:
    • Jian-Li Gao
    • Jun-Min Shi
    • Kai He
    • Qing-Wen Zhang
    • Shao-Ping Li
    • Simon Ming-Yuen Lee
    • Yi-Tao Wang

  • View Affiliations

  • Published online on: October 1, 2008     https://doi.org/10.3892/or_00000079
  • Pages: 819-824
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Yanhusuo (Corydalis yanhusuo W.T. Wang) is a well-known traditional Chinese medicine (TCM). In this study, we attempted to characterize in detail the signaling cascades that produce its anti-metastatic effect on the human breast cancer cell line, MDA-MB-231. We found that the yanhusuo extract inhibited the migration and invasion of MDA-MB-231 cells in vitro. In addition, the yanhusuo extract inhibited the mRNA expression and activity of metalloproteinase-9 (MMP-9). The anti-cancer metastasis effect of yanhusuo involved the activation of p38 and inhibition of ERK1/2 and SAPK/JNK mitogen-activated protein kinase (MAPK) signaling. Our experiments identified the biological activity of yanhusuo against cancer metastasis in vitro and provide a rationale for its further investigation.

Related Articles

Journal Cover

October 2008
Volume 20 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Gao J, Shi J, He K, Zhang Q, Li S, Lee SM and Wang Y: Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways. Oncol Rep 20: 819-824, 2008.
APA
Gao, J., Shi, J., He, K., Zhang, Q., Li, S., Lee, S.M., & Wang, Y. (2008). Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways. Oncology Reports, 20, 819-824. https://doi.org/10.3892/or_00000079
MLA
Gao, J., Shi, J., He, K., Zhang, Q., Li, S., Lee, S. M., Wang, Y."Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways". Oncology Reports 20.4 (2008): 819-824.
Chicago
Gao, J., Shi, J., He, K., Zhang, Q., Li, S., Lee, S. M., Wang, Y."Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways". Oncology Reports 20, no. 4 (2008): 819-824. https://doi.org/10.3892/or_00000079