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Glioma cells enhance endothelial progenitor cell angiogenesis via VEGFR-2, not VEGFR-1

  • Authors:
    • Junxia Zhang
    • Peng Zhao
    • Zhen Fu
    • Xiaolei Chen
    • Ning Liu
    • Ailin Lu
    • Rui Li
    • Lei Shi
    • Peiyu Pu
    • Chunsheng Kang
    • Yongping You

  • View Affiliations

  • Published online on: December 1, 2008     https://doi.org/10.3892/or_00000166
  • Pages: 1457-1463
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Although potential contribution of endothelial progenitor cells (EPCs) to angiogenesis in glioma has been proposed, the molecular mechanisms of EPCs recruitment to vasculature have not been fully elucidated. Here, we show that the supernatant from glioma cells promotes EPCs angiogenesis via VEGFR-2, not VEGFR-1. Moreover, VEGFR-2 siRNA inhibits VEGFR-2 expression in EPCs, tube formation on matrigel and cell migration. MMP-9 activity and expression and the Akt and ERK phosphorylations are decreased by VEGFR-2 siRNA. Thus, these results indicate that glioma cells enhance EPC angiogenesis via VEGFR-2, not VEGFR-1, mediated by the MMP-9, Akt and ERK signal pathways.

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Journal Cover

December 2008
Volume 20 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Zhang J, Zhao P, Fu Z, Chen X, Liu N, Lu A, Li R, Shi L, Pu P, Kang C, Kang C, et al: Glioma cells enhance endothelial progenitor cell angiogenesis via VEGFR-2, not VEGFR-1. Oncol Rep 20: 1457-1463, 2008.
APA
Zhang, J., Zhao, P., Fu, Z., Chen, X., Liu, N., Lu, A. ... You, Y. (2008). Glioma cells enhance endothelial progenitor cell angiogenesis via VEGFR-2, not VEGFR-1. Oncology Reports, 20, 1457-1463. https://doi.org/10.3892/or_00000166
MLA
Zhang, J., Zhao, P., Fu, Z., Chen, X., Liu, N., Lu, A., Li, R., Shi, L., Pu, P., Kang, C., You, Y."Glioma cells enhance endothelial progenitor cell angiogenesis via VEGFR-2, not VEGFR-1". Oncology Reports 20.6 (2008): 1457-1463.
Chicago
Zhang, J., Zhao, P., Fu, Z., Chen, X., Liu, N., Lu, A., Li, R., Shi, L., Pu, P., Kang, C., You, Y."Glioma cells enhance endothelial progenitor cell angiogenesis via VEGFR-2, not VEGFR-1". Oncology Reports 20, no. 6 (2008): 1457-1463. https://doi.org/10.3892/or_00000166