Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer

Winder,Thomas; Mündlein,Axel; Rhomberg,Simone; Dirschmid,Klaus; Hartmann,Bernd L.; Knauer,Michael; Drexel,Heinz; Wenzl,Etienne; De Vries,Alexander; Lang,Alois

doi:10.3892/or_00000352

May 2009 Volume 21 Issue 5

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May 2009 Volume 21 Issue 5

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Article

Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer

Authors:
- Thomas Winder
- Axel Mündlein
- Simone Rhomberg
- Klaus Dirschmid
- Bernd L. Hartmann
- Michael Knauer
- Heinz Drexel
- Etienne Wenzl
- Alexander De Vries
- Alois Lang
View Affiliations / Copyright

Affiliations: Department of Medicine, Academic Teaching Hospital Feldkirch, A-6807 Feldkirch, Austria. thomas.winder@lkhf.at
Pages: 1283-1287
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Published online on: May 1, 2009

https://doi.org/10.3892/or_00000352
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Abstract

A glycine to valine substitution at codon 12 (G12V) in Kirsten-Ras (K-Ras) gene has been associated with reduced overall survival in colorectal cancer patients; however, the effect of other K-Ras mutations than G12V still remains unclear. Therefore, we investigated the role of different K-Ras mutations on overall survival in a homogeneous, large patient cohort with standardized therapy and uniform analysis of K-Ras mutation status. The study included 342 patients with histopathologically proven colorectal cancer. Survival data were provided by the federal agency for statistics in Austria. Occurrence of K-Ras mutations at codons 12, 13 and 61 were determined by capillary sequencing. The overall K-Ras mutation frequency in carcinoma tissue was 28%. Carriers of the G12V mutation at the K-Ras gene showed a significantly decreased overall survival compared to carriers of the wild-type [HR=2.56 (1.15-5.69)]. Other mutations than G12V were associated with better overall survival compared to wild-type [HR=0.44 (0.2-0.99)]. In conclusion, for the first time, our study showed clearly that different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer

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Abstract

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