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HSP90 and its inhibitors (Review)

  • Authors:
    • Huifang Hao
    • Yoshio Naomoto
    • Xiaohong Bao
    • Nobuyuki Watanabe
    • Kazufumi Sakurama
    • Kazuhiro Noma
    • Takayuki Motoki
    • Yasuko Tomono
    • Takuya Fukazawa
    • Yasuhiro Shirakawa
    • Tomoki Yamatsuji
    • Junji Matsuoka
    • Munenori Takaoka

  • View Affiliations

  • Published online on: June 1, 2010     https://doi.org/10.3892/or_00000787
  • Pages: 1483-1492
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The HSP90 molecular chaperone family is highly conserved and expressed in various organisms ranging from prokaryotes to eukaryotes. HSP90 proteins play essential housekeeping functions, such as controlling the activity, turnover and trafficking of various proteins, promoting cell survival through maintaining the structural and functional integrity of some client proteins which control cell survival, proliferation and apoptosis, and play an important role in the progression of malignant disease. HSP90 proteins are ATP-dependent chaperones and the binding and hydrolysis of ATP are coupled to conformation changes of HSP90, which facilitate client protein folding and maturation. Many natural and synthetic molecular compounds have been proposed as promising cancer therapy via disrupting the formation of complex ATP-HSP90-client proteins.

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Journal Cover

June 2010
Volume 23 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Hao H, Naomoto Y, Bao X, Watanabe N, Sakurama K, Noma K, Motoki T, Tomono Y, Fukazawa T, Shirakawa Y, Shirakawa Y, et al: HSP90 and its inhibitors (Review). Oncol Rep 23: 1483-1492, 2010.
APA
Hao, H., Naomoto, Y., Bao, X., Watanabe, N., Sakurama, K., Noma, K. ... Takaoka, M. (2010). HSP90 and its inhibitors (Review). Oncology Reports, 23, 1483-1492. https://doi.org/10.3892/or_00000787
MLA
Hao, H., Naomoto, Y., Bao, X., Watanabe, N., Sakurama, K., Noma, K., Motoki, T., Tomono, Y., Fukazawa, T., Shirakawa, Y., Yamatsuji, T., Matsuoka, J., Takaoka, M."HSP90 and its inhibitors (Review)". Oncology Reports 23.6 (2010): 1483-1492.
Chicago
Hao, H., Naomoto, Y., Bao, X., Watanabe, N., Sakurama, K., Noma, K., Motoki, T., Tomono, Y., Fukazawa, T., Shirakawa, Y., Yamatsuji, T., Matsuoka, J., Takaoka, M."HSP90 and its inhibitors (Review)". Oncology Reports 23, no. 6 (2010): 1483-1492. https://doi.org/10.3892/or_00000787