Low SMC1A protein expression predicts poor survival in acute myeloid leukemia

  • Authors:
    • Claudia Hömme
    • Utz Krug
    • Nicola Tidow
    • Bernd Schulte
    • Gabriele Kühler
    • Hubert Serve
    • Horst Bürger
    • Wolfgang E. Berdel
    • Martin Dugas
    • Achim Heinecke
    • Thomas Büchner
    • Steffen Koschmieder
    • Carsten Müller-Tidow
  • View Affiliations

  • Published online on: July 1, 2010     https://doi.org/10.3892/or_00000827
  • Pages: 47-56
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Age is a strong adverse prognostic factor in acute myeloid leukemia. Little is known about the biology of acute myeloid leukemia in elderly patients. The aim of this study was to identify genes with age-dependent changes of expression in leukemic blasts and their relevance for the patient prognosis. Gene expression profiling was carried out by mRNA microarray analysis from blasts of 67 adult acute myeloid leukemia patients of different age (range, 17-80 years). Among the genes that correlated with age, PRPF4 and SMC1A were selected for protein expression studies on a tissue array containing bone marrow histologies of 135 patients with newly diagnosed AML of different ages. A significant correlation between mRNA expression levels and patient age was shown by 131 genes. Increasing age was associated with significantly decreased mRNA levels of SMC1A. On the protein level, expression of SMC1A was low or absent in 74 out of 116 acute myeloid leukemia specimens. Importantly, patients with low protein expression levels of SMC1A experienced significantly shortened event free (2.6 months versus 10.3 months, p=0.003) and overall survival (10.4 months versus 22.6 months, p=0.015). The SMC1A protein expression level remained a significant prognostic factor for event free survival (p=0.014) with a borderline significance for overall survival (p=0.066) in a multivariate analysis. SMC1A protein expression might play a role in the determination of the prognosis and might have possible implications in therapy decision in patients with acute myeloid leukemia.

Related Articles

Journal Cover

July 2010
Volume 24 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hömme C, Krug U, Tidow N, Schulte B, Kühler G, Serve H, Bürger H, Berdel WE, Dugas M, Heinecke A, Heinecke A, et al: Low SMC1A protein expression predicts poor survival in acute myeloid leukemia. Oncol Rep 24: 47-56, 2010.
APA
Hömme, C., Krug, U., Tidow, N., Schulte, B., Kühler, G., Serve, H. ... Müller-Tidow, C. (2010). Low SMC1A protein expression predicts poor survival in acute myeloid leukemia. Oncology Reports, 24, 47-56. https://doi.org/10.3892/or_00000827
MLA
Hömme, C., Krug, U., Tidow, N., Schulte, B., Kühler, G., Serve, H., Bürger, H., Berdel, W. E., Dugas, M., Heinecke, A., Büchner, T., Koschmieder, S., Müller-Tidow, C."Low SMC1A protein expression predicts poor survival in acute myeloid leukemia". Oncology Reports 24.1 (2010): 47-56.
Chicago
Hömme, C., Krug, U., Tidow, N., Schulte, B., Kühler, G., Serve, H., Bürger, H., Berdel, W. E., Dugas, M., Heinecke, A., Büchner, T., Koschmieder, S., Müller-Tidow, C."Low SMC1A protein expression predicts poor survival in acute myeloid leukemia". Oncology Reports 24, no. 1 (2010): 47-56. https://doi.org/10.3892/or_00000827