Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3
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- Published online on: July 1, 2010 https://doi.org/10.3892/or_00000846
- Pages: 195-201
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Abstract
Extensive data indicate that miR-21 plays a critical role in gliomagenesis, however, knowledge is limited on the mechanism of action of miR-21, including cell proliferation, apoptosis, and migration. In this study, we showed that down-regulation of miR-21 expression by antisense oligonucleotides inhibited glioma cell proliferation and induced cell apoptosis. Moreover, reduction of miR-21 activated caspase 9 and 3, which may be mediated by modulating multiple potential target genes, such as TIMP3. Together, these findings indicate that miR-21 plays a key role in regulating cell apoptosis in gliomas and may serve as a target for effective therapies.
