COVID‑19 and HIV: Case reports of 2 co‑infected patients with different disease courses

Alberca,Ricardo Wesley; Aoki,Valeria; Sato,Maria Notomi

doi:10.3892/wasj.2020.75

COVID‑19 and HIV: Case reports of 2 co‑infected patients with different disease courses

Authors:
- Ricardo Wesley Alberca
- Valeria Aoki
- Maria Notomi Sato
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Affiliations: Laboratory of Dermatology and Immunodeficiencies, LIM‑56, Department of Dermatology, School of Medicine and Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, SP 05403‑000, Brazil
Published online on: November 26, 2020 https://doi.org/10.3892/wasj.2020.75
Article Number: 4
Copyright: © Alberca et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The ongoing coronavirus disease 2019 (COVID‑19) pandemic has affected thousands of patients and thousands have also succumbed to the disease. The literature reports risk factors, such as obesity, diabetes and an older age. However, the association between immunosuppression caused by diseases, such as human immunodeficiency virus (HIV), and COVID‑19 has been rarely reported. In the present study, the cases of 2 HIV‑infected individuals (aged 48 and 49 years) with COVID‑19 symptoms are presented. At 4 days following the onset of COVID‑19 symptoms, the patients tested positive for the syndrome due to coronavirus‑2 (SARS‑CoV‑2) infection by RT‑PCR. The patients were hospitalized in the general ward of a tertiary university hospital for COVID‑19 patients (Hospital das Clinicas from the Medical School of the University of São Paulo), until discharge. Both patients were age‑matched HIV‑positive patients and presented different SARS‑CoV‑2 infection courses. In summary, the findings reported herein highlight that HIV‑infected individuals may be a high‑risk group for developing severe COVID‑19, particularly in association with other risk factors, such as obesity, type 2 diabetes mellitus and systemic arterial hypertension.

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1	Jambo KC, Sepako E, Fullerton DG, Mzinza D, Glennie S, Wright AK, Heyderman RS and Gordon SB: Bronchoalveolar CD4⁺ T cell responses to respiratory antigens are impaired in HIV-infected adults. Thorax. 66:375–382. 2011.PubMed/NCBI View Article : Google Scholar
2	Härter G, Spinner CD, Roider J, Bickel M, Krznaric I, Grunwald S, Schabaz F, Gillor D, Postel N, Mueller MC, et al: COVID-19 in people living with human immunodeficiency virus: A case series of 33 patients. Infection. 48:681–686. 2020.PubMed/NCBI View Article : Google Scholar
3	Hussain N, Yoganathan A, Hewage S, Alom S and Harky A: The effect of antivirals on COVID-19: A systematic review. Expert Rev Anti Infect Ther: Oct 20, 2020 (Epub ahead of print).
4	Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, Wang T, Zhang X, Chen H, Yu H, et al: Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 130:2620–2629. 2020.PubMed/NCBI View Article : Google Scholar
5	Branco ACCC, Sato MN and Alberca RW: The possible dual role of the ACE2 receptor in asthma and coronavirus (SARS-CoV2) infection. Front Cell Infect Microbiol. 10(550571)2020.PubMed/NCBI View Article : Google Scholar
6	Alberca RW, Pereira NZ, Oliveira LMDS, Gozzi-Silva SC and Sato MN: Pregnancy, viral infection, and COVID-19. Front Immunol. 11(1672)2020.PubMed/NCBI View Article : Google Scholar
7	Alberca RW: Asthma endotypes and COVID-19. J Asthma: Oct 1, 2020 (Epub ahead of print).
8	Mirzaei H, McFarland W, Karamouzian M and Sharifi H: COVID-19 among people living with HIV: a systematic review. AIDS Behav: Jul 30, 2020 (Epub ahead of print).
9	Alberca RW, Yendo TM, Leuzzi Ramos YÁ, Fernandes IG, Oliveira LM, Teixeira FME, Beserra DR, de Oliveira EA, Gozzi-Silva SC, Andrade MMS, et al: Case report: COVID-19 and Chagas disease in Two coinfected patients. Am J Trop Med Hyg: Oct 6, 2020 (Epub ahead of print).
10	Marino A, Pampaloni A, Scuderi D, Cosentino F, Moscatt V, Ceccarelli M, Gussio M, Celesia BM, Bruno R, Borraccino S, Borraccino S, et al: High-flow nasal cannula oxygenation and tocilizumab administration in patients critically ill with COVID-19: A report of three cases and a literature review. World Acad Sci J. 2(23)2020.
11	Chen H, Zhang L, He Z, Wang D, Liu L, Xhang W, Chen T, Dai Z, Han Z and Chen M: Systemic administration of human umbilical cord-derived mesenchymal stem cells effectively ameliorates the outcomes of a critically ill elderly patient with COVID-19 with multiple comorbidities: A case report. World Acad Sci J. 2(29)2020.
12	Alberca RW, Teixeira FME, Beserra DR, de Oliveira EA, Andrade MMS, Pietrobon AJ and Sato MN: Perspective: The Potential Effects of Naringenin in COVID-19. Front Immunol. 11(570919)2020.PubMed/NCBI View Article : Google Scholar
13	Liu Y, Du X, Chen J, Jin Y, Peng L, Wang HHX, Luo M, Chen L and Zhao Y: Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19. J Infect. 81:e6–e12. 2020.PubMed/NCBI View Article : Google Scholar
14	Alberca RW, Andrade MMS, Branco ACCC, Pietrobon AJ, Pereira NZ, Fernandes IG, Oliveira LM, Teixeira FME, Beserra DR, de Oliveira EA, et al: Frequencies of CD33+CD11b+ HLA-DR-CD14-CD66b+ and CD33+CD11b+HLA-DR-CD14+ CD66b- cells in peripheral blood as severity immune biomarkers in COVID-19. Front Med (Lausanne). 7(580677)2020.PubMed/NCBI View Article : Google Scholar
15	de la Rica R, Borges M, Aranda M, Del Castillo A, Socias A, Payeras A, Rialp G, Socias L, Masmiquel L and Gonzalez-Freire M: Low albumin levels are associated with poorer outcomes in a case series of COVID-19 patients in Spain: a retrospective cohort study. Microorganisms. 8(1106)2020.PubMed/NCBI View Article : Google Scholar
16	Codo AC, Davanzo GG, Monteiro LB, de Souza GF, Muraro SP, Virgilio-da-Silva JV, Prodonoff JS, Carregari VC, de Biagi Junior CAO, Crunfli F, et al: Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1α/glycolysis dependent axis. Cell Metab. 32:498–499. 2020.PubMed/NCBI View Article : Google Scholar
17	Zhou Y, Fu B, Zheng X, Wang D, Zhao C, Qi Y, Sun R, Tian Z, Xu X and Wei H: Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients. Natl Sci Rev. 7:998–1002. 2020.
18	Liu F, Xu A, Zhang Y, Xuan W, Yan T, Pan K, Yu W and Zhang J: Patients of COVID-19 may benefit from sustained Lopinavir-combined regimen and the increase of Eosinophil may predict the outcome of COVID-19 progression. Int J Infect Dis. 95:183–191. 2020.PubMed/NCBI View Article : Google Scholar
19	Wang M, Luo L, Bu H and Xia H: One case of coronavirus disease 2019 (COVID-19) in a patient co-infected by HIV with a low CD4+ T-cell count. Int J Infect Dis. 96:148–150. 2020.PubMed/NCBI View Article : Google Scholar
20	Vizcarra P, Pérez-Elías MJ, Quereda C, Moreno A, Vivancos MJ, Dronda F, Casado JL, Moreno S, Pérez-Elías MJ, Fortún J, et al: COVID-19 ID Team: Description of COVID-19 in HIV-infected individuals: A single-centre, prospective cohort. Lancet HIV. 7:e554–e564. 2020.PubMed/NCBI View Article : Google Scholar
21	Agarwal N, Iyer D, Gabbi C, Saha P, Patel SG, Mo Q, Chang B, Goswami B, Schubert U, Kopp JB, et al: HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: Implications for HIV-specific pathogenesis of NAFLD. Sci Rep. 7(7)2017.PubMed/NCBI View Article : Google Scholar
22	Wanjalla CN, McDonnell WJ and Koethe JR: Adipose tissue T Cells in HIV/SIV infection. Front Immunol. 9(2730)2018.PubMed/NCBI View Article : Google Scholar
23	Alberca RW, Oliveira LM, Branco ACCC, Pereira NZ and Sato MN: Obesity as a risk factor for COVID-19: An overview. Crit Rev Food Sci Nutr: Jun 15, 2020 (Epub ahead of print).
24	Lukic L, Lalic NM, Rajkovic N, Jotic A, Lalic K, Milicic T, Seferovic JP, Macesic M and Gajovic JS: Hypertension in obese type 2 diabetes patients is associated with increases in insulin resistance and IL-6 cytokine levels: Potential targets for an efficient preventive intervention. Int J Environ Res Public Health. 11:3586–3598. 2014.PubMed/NCBI View Article : Google Scholar
25	Gervasoni C, Meraviglia P, Riva A, Giacomelli A, Oreni L, Minisci D, Atzori C, Ridolfo A and Cattaneo D: Clinical features and outcomes of patients with human immunodeficiency virus with COVID-19. Clin Infect Dis. 71:2276–2278. 2020.PubMed/NCBI View Article : Google Scholar
26	Cooper TJ, Woodward BL, Alom S and Harky A: Coronavirus disease 2019 (COVID-19) outcomes in HIV/AIDS patients: A systematic review. HIV Med. 21:567–577. 2020.PubMed/NCBI View Article : Google Scholar