Experience in the treatment of pulmonary nocardiosis: A report of a fatal case

Li,Yuhong; Liu,Hong; Shen,Youlu

doi:10.3892/wasj.2021.104

Experience in the treatment of pulmonary nocardiosis: A report of a fatal case

Authors:
- Yuhong Li
- Hong Liu
- Youlu Shen
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Affiliations: Department of Respiratory Medicine, Qinghai University Affiliated Hospital, Xining, Qinghai 810001, P.R. China, Department of Cardiovascular Medicine, Qinghai University Affiliated Hospital, Xining, Qinghai 810001, P.R. China
Published online on: April 27, 2021 https://doi.org/10.3892/wasj.2021.104
Article Number: 33
Copyright : © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Pulmonary nocardiosis is an opportunistic infection that is commonly observed in immunocompromised individuals and in those with chronic disease. The present study reports the case of a female patient who was diagnosed with an intermuscular abscess in the left leg and with pulmonary nocardiosis. The patient had a 20-year history of the use of paracetamol and codeine phosphate drugs for the alleviation of headaches. The patient was treated with linezolid and trimethoprim-sulfamethoxazole (TMP-SMX). The symptoms of the patient improved and the patient was discharged 14 days later. The drug was discontinued spontaneously following discharge and the patient then passed away two months later. On the whole, the present study highlights the importance of the early diagnosis and standard treatment for pulmonary nocardiosis.

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1	Ambrosioni J, Lew D and Garbino J: Nocardiosis: Updated clinical review and experience at a tertiary center. Infection. 38:89–97. 2010.PubMed/NCBI View Article : Google Scholar
2	Lebeaux D, Bergeron E, Berthet J, Djadi-Prat J, Mouniée D, Boiron P, Lortholary O and Rodriguez-Nava V: Antibiotic susceptibility testing and species identification of Nocardia isolates: A retrospective analysis of data from a French expert laboratory, 2010-2015. Clin Microbiol Infect. 25:489–495. 2019.PubMed/NCBI View Article : Google Scholar
3	Iida S, Kageyama A, Yazawa K, Uchiyama N, Toyohara T, Chohnabayashi N, Suzuki SI, Nomura F, Kroppenstedt RM and Mikami Y: Nocardia exalbida sp. nov., isolated from Japanese patients with nocardiosis. Int J Syst Evol Microbiol. 56:1193–1196. 2006.PubMed/NCBI View Article : Google Scholar
4	Kato K, Noguchi S, Naito K, Ikushima I, Hanaka T, Yamasaki K, Kawanami T and Yatera K: Pulmonary nocardiosis caused by Nocardia exalbida in a patient with lung cancer and radiation pneumonitis: A case report and literature review. Intern Med. 58:1605–1611. 2019.PubMed/NCBI View Article : Google Scholar
5	Bennett JE, Dolin R and Blaser MJ: Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases: 2-Volume Set. Elsevier Health Sciences, 2014.
6	Wilson JW: Nocardiosis: Updates and clinical overview. Mayo Clin Proc. 87:403–407. 2012.PubMed/NCBI View Article : Google Scholar
7	Chacón CF, Vicente R, Ramos F, Porta J, Lopez Maldonado A and Ansotegui E: Nocardia farcinica lung infection in a patient with cystic fibrosis and a lung transplant. Rev Esp Anestesiol Reanim. 62:161–164. 2015.PubMed/NCBI View Article : Google Scholar : (In English, Spanish).
8	Elenkov IJ: Glucocorticoids and the Th1/Th2 balance. Ann NY Acad Sci. 1024:138–146. 2004.PubMed/NCBI View Article : Google Scholar
9	Coulthard P, Bailey E and Patel N: Paracetamol (acetaminophen) for pain after oral surgery. Oral Surg. 7:81–86. 2014.
10	Patel N, Bailey E and Coulthard P: Opioids for pain after oral surgery. Oral Surg. 7:196–202. 2014.
11	Mehrian P, Esfandiari E, Karimi MA and Memari B: Computed tomography features of pulmonary nocardiosis in immunocompromised and immunocompetent patients. Pol J Radiol. 80:13–17. 2015.PubMed/NCBI View Article : Google Scholar
12	Valdezate S, Garrido N, Carrasco G, Medina-Pascual MJ, Villalón P, Navarro AM and Saéz-Nieto JA: Epidemiology and susceptibility to antimicrobial agents of the main Nocardia species in Spain. J Antimicrob Chemother. 72:754–761. 2017.PubMed/NCBI View Article : Google Scholar
13	Hashemi-Shahraki A, Heidarieh P, Bostanabad SZ, Hashemzadeh M, Feizabadi MM, Schraufnagel D and Mirsaeidi M: Genetic diversity and antimicrobial susceptibility of Nocardia species among patients with nocardiosis. Sci Rep. 5(17862)2015.PubMed/NCBI View Article : Google Scholar
14	Huang L, Chen X, Xu H, Sun L, Li C, Guo W, Xiang L, Luo G, Cui Y and Lu B: Clinical features, identification, antimicrobial resistance patterns of Nocardia species in China: 2009-2017. Diagn Microbiol Infect Dis. 94:165–172. 2019.PubMed/NCBI View Article : Google Scholar