Open Access

Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review

  • Authors:
    • Edoardo Campanella
    • Andrea Marino
    • Manuela Ceccarelli
    • Maria Gussio
    • Federica Cosentino
    • Vittoria Moscatt
    • Cristina Micali
    • Giuseppe Nunnari
    • Benedetto Maurizio Celesia
    • Bruno Cacopardo
  • View Affiliations

  • Published online on: March 10, 2022     https://doi.org/10.3892/wasj.2022.149
  • Article Number: 14
  • Copyright: © Campanella et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Patients with sickle cell disease (SCD) are more susceptible to severe coronavirus disease 2019 (COVID‑19) infection, in comparison with the general population, due to the possibility that the inflammatory state, along with hypoxia and hypercoagulability may increase the risk of developing acute SCD‑related complications. The present study reports the case of a 33‑year‑old female affected by SCD, who although vaccinated against COVID‑19, tested positive for SARS‑CoV‑2 and developed febrile pneumonia. During hospitalization, the patient complained about generalized intense pain, along with fever recurrence and increased inflammatory marker, procalcitonin and haemoglobin S levels. The patient was treated with an intravenous analgesic therapeutics cocktail in combination with red blood cell manual exchange procedure and broad‑spectrum antibiotic therapy, achieving the rapid resolution of pain and an improvement in the laboratory test results. From the case presented herein, it is thus suggested that patients with SCD and COVID‑19 infection need to be critically evaluated by clinicians, as such patients may develop severe outcomes, attributed to the overlap of two difficult to treat conditions.
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March-April 2022
Volume 4 Issue 2

Print ISSN: 2632-2900
Online ISSN:2632-2919

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Spandidos Publications style
Campanella E, Marino A, Ceccarelli M, Gussio M, Cosentino F, Moscatt V, Micali C, Nunnari G, Celesia BM, Cacopardo B, Cacopardo B, et al: Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review. World Acad Sci J 4: 14, 2022.
APA
Campanella, E., Marino, A., Ceccarelli, M., Gussio, M., Cosentino, F., Moscatt, V. ... Cacopardo, B. (2022). Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review. World Academy of Sciences Journal, 4, 14. https://doi.org/10.3892/wasj.2022.149
MLA
Campanella, E., Marino, A., Ceccarelli, M., Gussio, M., Cosentino, F., Moscatt, V., Micali, C., Nunnari, G., Celesia, B. M., Cacopardo, B."Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review". World Academy of Sciences Journal 4.2 (2022): 14.
Chicago
Campanella, E., Marino, A., Ceccarelli, M., Gussio, M., Cosentino, F., Moscatt, V., Micali, C., Nunnari, G., Celesia, B. M., Cacopardo, B."Pain crisis management in a patient with sickle cell disease during SARS‑CoV‑2 infection: A case report and literature review". World Academy of Sciences Journal 4, no. 2 (2022): 14. https://doi.org/10.3892/wasj.2022.149