Comparative analysis of serum titanium levels in patients with healthy dental implants and patients with peri‑implantitis: A cross sectional prospective study

Sharanappa,Mahantesha; Shetty,Vibha; Konuganti,Kranti; Subbaiah,Shobha; Chandrashekhar,Greeshma; Alva,Babashankar

doi:10.3892/wasj.2024.224

Comparative analysis of serum titanium levels in patients with healthy dental implants and patients with peri‑implantitis: A cross sectional prospective study

Authors:
- Mahantesha Sharanappa
- Vibha Shetty
- Kranti Konuganti
- Shobha Subbaiah
- Greeshma Chandrashekhar
- Babashankar Alva
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Affiliations: Department of Periodontology, Faculty of Dental Sciences, M S Ramaiyah University of Applied Sciences, Bangalore, Karnataka 560054, India, Department of Prosthodontics and Implantology, Faculty of Dental Sciences, M S Ramaiyah University of Applied Sciences, Bangalore, Karnataka 560054, India, Department of Periodontology, Oxford Dental College, Bangalore, Karnataka 560078, India
Published online on: January 11, 2024 https://doi.org/10.3892/wasj.2024.224
Article Number: 9
Copyright : © Sharanappa et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Titanium dental implants can last for more than two decades in the oral environment. The corrosion of the implant surface can release metallic particles or ions into surrounding tissue. The metallic constituents, such as titanium in human blood serum samples of patients with dental implants have not yet been extensively studied. The present study thus compared titanium serum levels before and after the placement of dental implants, and also compare the levels in patients with healthy implants and those with peri‑implantitis. The present study comprised of patients in group 1 selected for dental implant surgery and patients in group 2 diagnosed with peri‑implantitis. Each group comprised of 60 patients. Serum titanium levels were measured from blood samples obtained from patients in group 1 at three different intervals (at 1 month prior to implant surgery, and at the 4th and 8th month after successful loading) and from patients in group 2 during the course of peri‑implantitis by inductively coupled plasma‑mass spectroscopy. Statistical analysis was performed for the obtained data. The results revealed increased serum titanium level sat the 4th month post‑implant placement (2.39 mg/dl) and in patients with peri‑implantitis (2.94 mg/dl); both levels differed significantly (determined using ANOVA) from the pre‑surgical estimation data of serum titanium levels (1.79 mg/dl). On the whole, understanding the association between titanium corrosion and peri‑implantitis is vital for enhancing the long‑term success and safety of dental implants. Additional research is required to investigate these links and develop potential strategies that can be used to protect the well‑being of patients with dental implants.

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