Open Access

Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus

  • Authors:
    • Junior Carbajal
    • Carlos Ballon‑Salcedo
    • Leonardo J. Uribe‑Cavero
    • Gabriel G. Saravia
    • Sthefany S. Cuadros‑Aguilar
    • Maria J. Lopez
    • Alfredo Rebaza
    • Jhon Ausejo
    • Joseph A. Pinto
    • Kevin J. Paez
    • Luis G. Saravia‑Huarca
  • View Affiliations

  • Published online on: September 3, 2024     https://doi.org/10.3892/wasj.2024.277
  • Article Number: 62
  • Copyright : © Carbajal et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

The present study aimed to investigate the risk factors associated with the in‑hospital mortality of patients with coronavirus disease 2019 (COVID‑19) and type 2 diabetes mellitus (T2DM). Therefore, a cross‑sectional study of the medical records of patients hospitalized between April, 2020 and February, 2021 was performed. The demographic, clinical, laboratory and treatment data were compared between COVID‑19 survivors and non‑survivors. Furthermore, multivariate logistic regression and principal component analyses (PCA) were carried out to identify risk factors associated with mortality in these patients. Among the 287 patients included, 132 (46%) did not survive. The multivariate regression analysis revealed that dyspnea [odds ratio (OR), 7.68; 95% confidence interval (CI), 1.77‑40.89; P=0.010], neutrophil count >6.3x109/l (OR, 8.17; 95% CI, 3.16‑26.62; P<0.001), hemoglobin levels of ≤12 g/dl (OR, =3.24; 95% CI, 1.30‑8.56; P=0.014) and a partial pressure of oxygen (PaO2) of <60 mmHg (OR, 7.46; 95% CI, 2.83‑21.86; P<0.001) were independent risk factors for in‑hospital mortality. By contrast, lung crackles were associated with lower risk of in‑hospital mortality (OR, 0.21; 95% CI, 0.08‑0.55). In addition, PCA revealed that elevated levels of fraction of inspired oxygen (FiO2), blood urea nitrogen, serum creatinine and neutrophil count, and a low PaO2/FiO2 ratio considerably contributed to the first principal components of the non‑survivor group. Overall, the results of the present study demonstrated that patients with COVID‑19 and T2DM exhibit a high mortality rate, while several factors in these patients contribute independently to in‑hospital mortality.
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November-December 2024
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Spandidos Publications style
Carbajal J, Ballon‑Salcedo C, Uribe‑Cavero LJ, Saravia GG, Cuadros‑Aguilar SS, Lopez MJ, Rebaza A, Ausejo J, Pinto JA, Paez KJ, Paez KJ, et al: Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus. World Acad Sci J 6: 62, 2024.
APA
Carbajal, J., Ballon‑Salcedo, C., Uribe‑Cavero, L.J., Saravia, G.G., Cuadros‑Aguilar, S.S., Lopez, M.J. ... Saravia‑Huarca, L.G. (2024). Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus. World Academy of Sciences Journal, 6, 62. https://doi.org/10.3892/wasj.2024.277
MLA
Carbajal, J., Ballon‑Salcedo, C., Uribe‑Cavero, L. J., Saravia, G. G., Cuadros‑Aguilar, S. S., Lopez, M. J., Rebaza, A., Ausejo, J., Pinto, J. A., Paez, K. J., Saravia‑Huarca, L. G."Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus". World Academy of Sciences Journal 6.6 (2024): 62.
Chicago
Carbajal, J., Ballon‑Salcedo, C., Uribe‑Cavero, L. J., Saravia, G. G., Cuadros‑Aguilar, S. S., Lopez, M. J., Rebaza, A., Ausejo, J., Pinto, J. A., Paez, K. J., Saravia‑Huarca, L. G."Risk factors associated with the mortality of COVID‑19 in patients with type 2 diabetes mellitus". World Academy of Sciences Journal 6, no. 6 (2024): 62. https://doi.org/10.3892/wasj.2024.277