Association between TSH and creatinine levels in patients with hypothyroidism

Hwisa,Sara A.; Soliman,Namat A.; Faraj,Mofeda M.; Salem,Ghada M.; Alosta,Anaya M.; Alshoshan,Salsabiel O.; Alfituri,Retag F.; Aziez,Zaid A.

doi:10.3892/wasj.2024.288

Association between TSH and creatinine levels in patients with hypothyroidism

Authors:
- Sara A. Hwisa
- Namat A. Soliman
- Mofeda M. Faraj
- Ghada M. Salem
- Anaya M. Alosta
- Salsabiel O. Alshoshan
- Retag F. Alfituri
- Zaid A. Aziez
View Affiliations

Affiliations: Department of Medical and Basic Sciences, Faculty of Dentistry, University of Zawia, Zawia 16418, Libya, Department of Medical Technology, Faculty of Health Sciences University of Zawia, Zawia 16418, Libya, Libyan Authority for Scientific Research, Tripoli 80045, Libya, Department of Medical Technology, Higher Institute of Medical Sciences and Technologies, Tripoli 16418, Libya
Published online on: October 10, 2024 https://doi.org/10.3892/wasj.2024.288
Article Number: 73
Copyright : © Hwisa et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Thyroid hormones play a crucial role in regulating renal function, and hypothyroidism ranks among the most prevalent endocrine disorders worldwide. The present study aimed to investigate the association between thyroid stimulating hormone (TSH) levels and creatinine levels in patients with hypothyroidism. A descriptive cross‑sectional study design was applied, and a cohort of patients with hypothyroidism was recruited from medical centers. The age range of the participants was between 13 to 84 years. The patients were categorized into four groups based on their TSH values as follows: Group 1, patients with a TSH level >4.00 µIU/l; group 2, patients with a TSH level <0.46 µIU/l; group 3, patients with a TSH level ranging from 0.60 to 2.8 µIU/l; and group 4, patients with a TSH level ranging from 2.94 to 3.60 µIU/l. Among the 120 participants, consisting of 30 control subjects and 90 patients with hypothyroidism, 74 subjects not undergoing dialysis exhibited statistically significant differences in TSH and creatinine levels across the four hypothyroid groups (P<0.05). Correlation analysis revealed positive correlations between TSH and creatinine levels in groups 1 (r=0.446, P=0.043), 3 (r=0.541, P=0.001) and 4 (r=0.748, P=0.005). Conversely, a negative correlation was observed between TSH and creatinine levels in group 2 (r=‑0.892, P=0.001). The control group displayed a weak negative correlation between TSH and creatinine (r=‑0.367, P=0.046). The TSH levels exhibited positive correlations with creatinine levels in all groups, with the exception of group 2, where a negative correlation was observed. These findings suggest a potential association between thyroid function and kidney dysfunction. This observation highlights a complex interaction between thyroid function and kidney health. The positive correlation between TSH and creatinine levels in the majority of the groups suggests that higher TSH levels are associated with higher creatinine levels, indicating potential thyroid dysfunction and impaired kidney function. However, the negative correlation in group 2 suggests a different or even opposite relationship in that specific group.

View Figures

View References

1	Chaker L and Peeters RP: Thyroid-stimulating hormone. In The Pituitary. Academic Press, pp173-207, 2022.
2	Feher JJ: Quantitative human physiology: An introduction. Academic press, 2017.
3	Lerma EV, Sparks MA and Topf J: Nephrology secrets E-book. Elsevier Health Sciences, 2018.
4	Larsen T, See EJ, Holmes NE and Bellomo R: Estimating baseline creatinine to detect acute kidney injury in patients with chronic kidney disease. Nephrology. 28:434–445. 2023.PubMed/NCBI View Article : Google Scholar
5	Yang B, Zhou W, Cui L, Tian L, Ni Y, Yang M and Yang Y: The predictive value of free thyroxine combined with tubular atrophy/interstitial fibrosis for poor prognosis in patients with IgA nephropathy. Front Endocrinol (Lausanne). 15(1372824)2024.PubMed/NCBI View Article : Google Scholar
6	Simeoni M, Cerantonio A, Pastore I, Liguori R, Greco M, Foti D, Gulletta E, Brunetti A and Fuiano G: The correct renal function evaluation in patients with thyroid dysfunction. J Endocrinol Invest. 39:495–507. 2016.PubMed/NCBI View Article : Google Scholar
7	Liu ZX, Lv JL, Xiang YL, Deng W, Huang H, Sun YH and Li LH: The association between thyroid hormones and renal function in euthyroid Chinese individuals: A Population-Based Cross-Sectional study. Cureus. 16(e55682)2024.PubMed/NCBI View Article : Google Scholar
8	Rhee CM, Kalantar-Zadeh K, Streja E, Carrero JJ, Ma JZ, Lu JL and Kovesdy CP: The relationship between thyroid function and estimated glomerular filtration rate in patients with chronic kidney disease. Nephrol Dial Transplant. 30:282–287. 2015.PubMed/NCBI View Article : Google Scholar
9	Hu M, Asami C, Iwakura H, Nakajima Y, Sema R, Kikuchi T, Miyata T, Sakamaki K, Kudo T, Yamada M, et al: Development and preliminary validation of a machine learning system for thyroid dysfunction diagnosis based on routine laboratory tests. Commun Med (Lond). 2(9)2022.PubMed/NCBI View Article : Google Scholar
10	Kondaveeti SB and Shaker IA: Estimation of glycated albumin levels in various thyroid disorders. Int J Cur Res Rev. 6(138)2014.
11	Naguib R and Elkemary E: Thyroid dysfunction and renal function: A crucial relationship to recognize. Cureus. 15(e35242)2023.PubMed/NCBI View Article : Google Scholar
12	Attaullah S, Haq BS and Ahmed Z: Correlation of thyroid dysfunction with serum creatinine. Int J Multidiscip Res Dev. 2:88–90. 2015.
13	Akagunduz B and Akcakaya M: Evaluation of the correlation of urea, creatine, and uric acid levels with TSH in patients with newly diagnosed overt and subclinic hypothyroidism. Eurasian J Med Investigation. 5:317–321. 2021.
14	You AS, Kalantar-Zadeh K, Brent GA, Narasaki Y, Daza A, Sim JJ, Kovesdy CP, Nguyen DV and Rhee CM: Impact of thyroid status on incident kidney dysfunction and chronic kidney disease progression in a nationally representative cohort. Mayo Clin Proc. 99:39–56. 2024.PubMed/NCBI View Article : Google Scholar
15	Xing Y, Yang L, Liu J and Ma H: The Association with subclinical thyroid dysfunction and uric acid. Int J Endocrinol. 2021(9720618)2021.PubMed/NCBI View Article : Google Scholar
16	Yu W, Wang Y, Ma L, Gou S and Fu P: Analysis of thyroid function in ANCA-Associated vasculitis patients with renal injury. J Pers Med. 14(99)2024.PubMed/NCBI View Article : Google Scholar
17	Joo EY, Kim YJ, Go Y and Song JG: Relationship between perioperative thyroid function and acute kidney injury after thyroidectomy. Sci Rep. 8(13539)2018.PubMed/NCBI View Article : Google Scholar
18	Arora P, Prasad S and Karunanand B: Hospital based study of thyroid disorders in rural population of Gurgaon, Haryana. Int J Curr Res Rev. 8(6)2016.
19	Gurbuz AF and Yucel K: Effects of hypothyroidism and hyperthyroidism on hematological and biochemical parameters. Ann Clin Anal Med. 14 (Suppl 1):S10–S14. 2023.
20	Alsulami MO, Alharbi NM, Alsulami DW, Almaghrabi SJ, Albaradei HA and Alhozali AM: Association between blood pressure, glomerular filtration rate, and serum thyroid-stimulating hormone levels in hypothyroid patients: A retrospective Single-center study. Cureus. 14(e28686)2022.PubMed/NCBI View Article : Google Scholar
21	Jaiswal N and Nirwan DS: Study of serum creatinine level in hypothyroidism. J Mahatma Gandhi Univ Med Sci Tech. 3:79–81. 2018.
22	Kaur V, Singh K and Verma M: Changes in biochemical markers of renal function in subclinical and overt hypothyroidism. Int J Bioassays. 4:3799–3802. 2015.
23	Patil VP, Shilpasree AS, Patil VS, Pravinchandra KR, Ingleshwar DG and Vani AC: Evaluation of renal function in subclinical hypothyroidism. J Lab Physicians. 10:50–55. 2018.PubMed/NCBI View Article : Google Scholar
24	Marwah S, Mehta M, Shah H, Haridas N and Trivedi A: Correlation of serum uric acid and serum creatinine in hypothyroidism. Natl J Physiol Pharm Pharmacol. 5:232–235. 2015.
25	Thadani D, Kumawat M, Mahawar S and Jain A: Evaluation of serum creatinine level in subclinical hypothyroidism. GJRA. 10:29–32. 2021.
26	Mahantesh BB, Shankar Prasad DS and Sangappa VKSG: Evaluation of serum creatinine in subclinical hypothyroidism. A case-control study. Int J Clin Biochemistry Res. 2:182–184. 2015.
27	Al Fahdi I, Al Salmi I, Al Rahbi F, Shaheen F and Hannawi S: Thyroid dysfunction and kidney dysfunction. Oman Med J. 37(e377)2022.PubMed/NCBI View Article : Google Scholar
28	Awad RA, Mohan D, Alalawi F, Railey M and Alhadari A: An interesting case of hypothyroidism associated acute kidney injury. Indian J Nephrol. 33:220–224. 2023.PubMed/NCBI View Article : Google Scholar
29	Tani H, Hirashio S, Tsuda A, Tachiyama Y, Hara S and Masaki T: Renal dysfunction caused by severe hypothyroidism diagnosed by renal biopsy: A case report. CEN Case Rep: February 28, 2024 (Epub ahead of print).
30	Jia D, Liang LB, Tang GH, He H, Zhang M, Li ZP and Li SQ: The association between serum uric acid and creatinine in patients with hypothyroidism. Sichuan Da Xue Xue Bao Yi Xue Ban. 46:747–749. 2015.PubMed/NCBI(In Chinese).
31	Yosuf LM: Study the correlation between thyroid disorder and chronic kidney failure. Uni Thi-Qar J Sci. 9:59–65. 2022.
32	Kumari B, Kumar P, Keshari JR, Kumar A, Pankaj S and Chaudhary RKP: Serum BUN and creatinine estimation in patients of overt hypothyroidism: A case control study. Int J Res Med Sci. 5(3990)2017.
33	Ghosh M, Bandyopadhyay K, Sinha B and Kanti M: Evaluation of kidney function in hypothyroid subjects and its correlation with FT4 & TSH level. Int J Acad Med Pharm. 5:1928–1931. 2023.
34	Kumar GR and Priyadarshini DV: A study on comparison of serum creatinine, serum uric acid and serum zinc levels in hypothyroid and healthy controls-at a tertiary care hospital. Int J Adv Biochem Res. 3:18–20. 2019.
35	Singh AK, Kumar R, Sharma A, Sharma D and Srivastava S: Renal function derangements in hypothyroidism: A clinical correlation between serum creatinine, urea and uric acid levels. Int J Clin Biochem Res. 5:533–536. 2018.
36	Shrivatsava S: A study of serum uric acid levels and serum creatinine levels in hypothyroidism. Int J Clin Biochem Res. 9:148–153. 2022.