Open Access

Adjusted polygenic risk score: A novel biomarker for the prevention of cardiovascular diseases 

  • Authors:
    • Effie Salata
    • Thanos Fotis
    • Eleni Ntoumou
    • Alexis Sagonas
    • Nikolaos Panagiotou
  • View Affiliations

  • Published online on: February 6, 2025     https://doi.org/10.3892/wasj.2025.320
  • Article Number: 32
  • Copyright : © Salata et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Accurate risk assessment is crucial for effective cardiovascular disease (CVD) prevention. Traditional methods often underestimate the risk, particularly in those with genetic predisposition. The present study introduces a novel approach integrating polygenic risk scores (PRS) with lifestyle factors in an aim to enhance risk assessment. Buccal swab samples from 287 healthy individuals (utilizing only pre‑existing anonymized genetic data) were used to calculate PRS and adjusted PRS (Adj‑PRS). The analysis revealed significant associations between PRS, Adj‑PRS and cardiovascular risk factors. In a separate cohort of 291 individuals, significant associations were demonstrated between Adj‑PRS and hypertension, body mass index, salt consumption, exercise levels, and smoking status. Overall, the findings presented herein highlight the utility of PRS and Adj‑PRS in refining cardiovascular risk assessment and identifying individuals who are at an increased risk of developing CVD and who may benefit from targeted preventive interventions. This novel approach has implications for personalized medicine and may contribute to more effective CVD prevention strategies in clinical practice.
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May-June 2025
Volume 7 Issue 3

Print ISSN: 2632-2900
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Copy and paste a formatted citation
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Spandidos Publications style
Salata E, Fotis T, Ntoumou E, Sagonas A and Panagiotou N: Adjusted polygenic risk score: A novel biomarker for the prevention of cardiovascular diseases . World Acad Sci J 7: 32, 2025.
APA
Salata, E., Fotis, T., Ntoumou, E., Sagonas, A., & Panagiotou, N. (2025). Adjusted polygenic risk score: A novel biomarker for the prevention of cardiovascular diseases . World Academy of Sciences Journal, 7, 32. https://doi.org/10.3892/wasj.2025.320
MLA
Salata, E., Fotis, T., Ntoumou, E., Sagonas, A., Panagiotou, N."Adjusted polygenic risk score: A novel biomarker for the prevention of cardiovascular diseases ". World Academy of Sciences Journal 7.3 (2025): 32.
Chicago
Salata, E., Fotis, T., Ntoumou, E., Sagonas, A., Panagiotou, N."Adjusted polygenic risk score: A novel biomarker for the prevention of cardiovascular diseases ". World Academy of Sciences Journal 7, no. 3 (2025): 32. https://doi.org/10.3892/wasj.2025.320