Open Access

Pharmacogenetic‑guided treatment in major depressive disorder

  • Authors:
    • Nikolaos Panagiotou
    • Alexis Sagonas
    • Eleni Ntoumou
    • Effie Salata
    • Thanos Fotis
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  • Published online on: February 6, 2025     https://doi.org/10.3892/wasj.2025.321
  • Article Number: 33
  • Copyright : © Panagiotou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Depression affects millions of individuals worldwide, presenting a significant challenge for clinicians striving to match patients with effective treatments. Conventional antidepressant therapy involves a trial‑and‑error approach, leading to delayed relief, increased healthcare costs and patient distress. Recent advancements in pharmacogenetics provide a promising avenue for personalized treatment, leveraging genetic information to optimize medication selection and dosage adjustments. The present study aimed to investigate the extent of genetic polymorphisms that affect antidepressant drug metabolism and efficacy in a psychiatric population. Additionally, the present study investigated pharmacogenetic‑guided treatment outcomes in a sub‑population of patients diagnosed with major depressive disorder. Pharmacogenetic‑guided therapy represents a novel strategy which can be used to personalize depression treatment, providing the potential to enhance efficacy, safety and patient satisfaction. While challenges persist, accumulating evidence supports its integration into routine clinical practice, heralding a new era of precision medicine in mental health care.
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May-June 2025
Volume 7 Issue 3

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Spandidos Publications style
Panagiotou N, Sagonas A, Ntoumou E, Salata E and Fotis T: Pharmacogenetic‑guided treatment in major depressive disorder. World Acad Sci J 7: 33, 2025.
APA
Panagiotou, N., Sagonas, A., Ntoumou, E., Salata, E., & Fotis, T. (2025). Pharmacogenetic‑guided treatment in major depressive disorder. World Academy of Sciences Journal, 7, 33. https://doi.org/10.3892/wasj.2025.321
MLA
Panagiotou, N., Sagonas, A., Ntoumou, E., Salata, E., Fotis, T."Pharmacogenetic‑guided treatment in major depressive disorder". World Academy of Sciences Journal 7.3 (2025): 33.
Chicago
Panagiotou, N., Sagonas, A., Ntoumou, E., Salata, E., Fotis, T."Pharmacogenetic‑guided treatment in major depressive disorder". World Academy of Sciences Journal 7, no. 3 (2025): 33. https://doi.org/10.3892/wasj.2025.321