STUDY OF THE INTERRELATIONSHIP ANGIOGENESIS-INFLAMMATION-OXIDATIVE STRESS IN PATIENTS DIAGNOSED WITH INFLAMMATORY BOWEL DISEASES

Although the research of the last decades led to the discovery of biological therapy with human monoclonal antibodies, which allowed a better regulation of the activity of the cellular immune response and the inflammation of the intestinal mucosa, with clinical remission and endoscopic healing, there are patients in whom mucosal healing is not observed or altering the natural history of inflammatory bowel disease. Starting from these observations, we propose in this special issue to collect important studies, both preliminary ones, regarding the evaluation of angiogenic, inflammatory status, and oxidative stress in patients with IBD. Studies investigating the hypothesis that angiogenesis and oxidative stress contribute significantly to mucosal inflammation in IBD are also welcome. Studying the interrelation between angiogenic factors - inflammatory markers - oxidative stress factors can lead to an objective measurement of disease activity, because symptoms are often subjective, and invasive procedures are often a burden for the patient.

10/07/2025