Effect of ephedrine combined with bupivacaine on maternal hemodynamic and spinal nerve block in cesarean delivery

  • Authors:
    • Mingyue Ge
    • Sheng Wang
    • Zhigang Dai
    • Yan Li
    • Liping Xie
    • Xuejao Liu
    • Jiangwen Yin
  • View Affiliations

  • Published online on: January 25, 2017     https://doi.org/10.3892/br.2017.846
  • Pages: 295-299
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Abstract

The aim of the study was to investigate the effects of ephedrine intrathecal injection on maternal thermodynamics and spinal nerve block in cesarean section. A total of 107 patients undergoing elective cesarean section under combined spinal epidural anesthesia were randomly divided into two groups: group E: Bupivacaine (6 mg) combined with ephedrine (15 mg) and group C: Bupivacaine (6 mg). Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), the incidence of hypotension, hypertension, tachycardia, nausea and vomiting were all recorded. The umbilical vein blood gases and noradrenaline, as well as maternal peripheral venous blood were analyzed. The time of high‑quality spinal block was also recorded. Postoperatively, 1 day, 2 days bedside follow‑up and 7, 21, 35 days telephone follow‑up were carried out to determine any neurological deficit maternal performance. SBP and DBP decreased in group C but not in group E at 3 min after spinal anesthesia and 1 min after delivery (P<0.05). From 3 min post‑anesthesia to the end of surgery, the HR levels in the C group were significantly higher than those of the E group (P<0.05). The incidence of hypotension, tachycardia, nausea and vomiting and neonate acidosis was low in group E compared with group C (P<0.05). The time of high‑quality spinal block in group E was longer than that of group C (P<0.05). After spinal anesthesia, the concentration of noradrenaline from maternal peripheral venous blood was low in group C but high in group E compared with before spinal anesthesia (P<0.05). Ephedrine combined with low‑dose bupivacaine intrathecal injection effectively maintained maternal hemodynamics and prolonged the time of sensory spinal block.
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March-2017
Volume 6 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Ge M, Wang S, Dai Z, Li Y, Xie L, Liu X and Yin J: Effect of ephedrine combined with bupivacaine on maternal hemodynamic and spinal nerve block in cesarean delivery. Biomed Rep 6: 295-299, 2017
APA
Ge, M., Wang, S., Dai, Z., Li, Y., Xie, L., Liu, X., & Yin, J. (2017). Effect of ephedrine combined with bupivacaine on maternal hemodynamic and spinal nerve block in cesarean delivery. Biomedical Reports, 6, 295-299. https://doi.org/10.3892/br.2017.846
MLA
Ge, M., Wang, S., Dai, Z., Li, Y., Xie, L., Liu, X., Yin, J."Effect of ephedrine combined with bupivacaine on maternal hemodynamic and spinal nerve block in cesarean delivery". Biomedical Reports 6.3 (2017): 295-299.
Chicago
Ge, M., Wang, S., Dai, Z., Li, Y., Xie, L., Liu, X., Yin, J."Effect of ephedrine combined with bupivacaine on maternal hemodynamic and spinal nerve block in cesarean delivery". Biomedical Reports 6, no. 3 (2017): 295-299. https://doi.org/10.3892/br.2017.846