Reduction in miRNA-125b-5p levels is associated with obstructive renal injury

  • Authors:
    • Silu Wang
    • Lianfeng Wu
    • Linyong Du
    • Hong Lu
    • Bicheng Chen
    • Yongheng Bai
  • View Affiliations

  • Published online on: Friday, March 17, 2017
  • Pages:449-454 DOI: 10.3892/br.2017.875
0

Abstract

Obstructive renal injury is a common disease that leads to progressive glomerulosclerosis, tubulointerstitial fibrosis and loss of renal function. MicroRNAs (miRNAs/miRs) are small non-coding molecules that may be involved in the progression of many renal diseases. The aim of the present study was to investigate the roles of miRNAs, including miR‑125b, miR‑326 and miR‑324p, in obstructive renal injury. Blood samples were collected from 91 patients with ureteral obstruction and 76 controls to examine renal function. In addition, the levels of miR‑125b, miR‑326 and miR‑324p in patients with ureteral obstruction and controls were determined by the reverse transcription‑quantitative polymerase chain reaction. Furthermore, the relationship between miRNA levels and renal function was evaluated by the Mann‑Whitney U test. Upregulated levels of serum creatinine (SCr) in patients with ureteral obstruction were observed, identifying the injury of renal function. Although the expression levels of miR‑324‑5p [1.003 (0.391‑2.279) vs. 0.934 (0.579‑1.539), P=0.300] and miR‑326 [0.840 (0.180‑2.020) vs. 0.949 (0.507‑1.702), P=0.050] presented no significant difference, the levels of miR‑125b‑5p [0.755 (0.210‑2.110) vs. 0.960 (0.390‑1.770), P=0.002] in patients with ureteral obstruction were significantly lower than those in controls. These results indicated that there is a stronger correlation of miR‑125b‑5p with the occurrence of ureteral obstruction, especially for the female (P=0.0171) and elderly (P=0.0142). Furthermore, the levels of miR‑125b‑5p (r=‑0.175, P=0.038) were closely associated with the serum levels of SCr, suggesting a key role of miR‑125b‑5p in renal dysfunction. Thus, these findings suggested that miR‑125b‑5p in patients with ureteral obstruction correlated with renal function, and may be a potential biomarker for obstructive renal injury.

Related Articles

Journal Cover

April 2017
Volume 6 Issue 4

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Wang, S., Wu, L., Du, L., Lu, H., Chen, B., & Bai, Y. (2017). Reduction in miRNA-125b-5p levels is associated with obstructive renal injury. Biomedical Reports, 6, 449-454. http://dx.doi.org/10.3892/br.2017.875
MLA
Wang, S., Wu, L., Du, L., Lu, H., Chen, B., Bai, Y."Reduction in miRNA-125b-5p levels is associated with obstructive renal injury". Biomedical Reports 6.4 (2017): 449-454.
Chicago
Wang, S., Wu, L., Du, L., Lu, H., Chen, B., Bai, Y."Reduction in miRNA-125b-5p levels is associated with obstructive renal injury". Biomedical Reports 6, no. 4 (2017): 449-454. http://dx.doi.org/10.3892/br.2017.875