Smart watch‑based coaching with tiotropium and olodaterol ameliorates physical activity in patients with chronic obstructive pulmonary disease

Hataji,Osamu; Nishii,Yoichi; Ito,Kentaro; Sakaguchi,Tadashi; Saiki,Haruko; Suzuki,Yuta; D'Alessandro‑Gabazza,Corina; Fujimoto,Hajime; Kobayashi,Tetsu; Gabazza,Esteban  C.; Taguchi,Osamu

doi:10.3892/etm.2017.5088

Smart watch‑based coaching with tiotropium and olodaterol ameliorates physical activity in patients with chronic obstructive pulmonary disease

Authors:
- Osamu Hataji
- Yoichi Nishii
- Kentaro Ito
- Tadashi Sakaguchi
- Haruko Saiki
- Yuta Suzuki
- Corina D'Alessandro‑Gabazza
- Hajime Fujimoto
- Tetsu Kobayashi
- Esteban C. Gabazza
- Osamu Taguchi
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Affiliations: Respiratory Center, Matsusaka Municipal Hospital, Matsusaka, Mie 515‑8544, Japan, Department of Immunology, Mie University Faculty and Graduate School of Medicine, Tsu, Mie 514‑8507, Japan, Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine, Tsu, Mie 514‑8507, Japan, Mental and Physical Health Center, Mie University Faculty and Graduate School of Medicine, Tsu, Mie 514‑8507, Japan
Published online on: September 1, 2017 https://doi.org/10.3892/etm.2017.5088
Pages: 4061-4064
Copyright: © Hataji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Combined therapy with tiotropium and olodaterol notably improves parameters of lung function and quality of life in patients with chronic obstructive pulmonary disease (COPD) compared to mono‑components; however, its effect on physical activity is unknown. The present study evaluated whether combination therapy affects daily physical performance in patients with COPD under a smart watch‑based encouragement program. This was a non‑blinded clinical trial with no randomization or placebo control. A total of 20 patients with COPD were enrolled in the present study. The patients carried an accelerometer for 4 weeks; they received no therapy during the first 2 weeks but they were treated with combined tiotropium and olodaterol under a smart watch‑based encouragement program for the last 2 weeks. The pulmonary function test, COPD assessment test, 6‑min walk distance and parameters of physical activity were significantly improved (P<0.05) by combination therapy under smart watch‑based coaching compared with values prior to treatment. To the best of our knowledge, the present study for the first time provides evidence that smart watch‑based coaching in combination with tiotropium and olodaterol may improve daily physical activity in chronic obstructive pulmonary disease.

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