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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April 2005 Volume 15 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Relevance of nuclear localization and functions of RNA helicase A

Hidetoshi Fujita, Takayuki Ohshima, Takayuki Oishi, Satoko Aratani, Ryouji Fujii, Akiyoshi Fukamizu, Toshihiro Nakajima
Pages: 555-560
Published online on: 01 April 2005

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Article

Evolution of interleukin-18 binding proteins and interleukin-1 receptor, type II proteins

Makoto Watanabe, Naohisa Goto, Yuko Watanabe, Seiji Nishiguchi, Kazunori Shimada, Teruo Yasunga, Hiromichi Yamanishi
Pages: 561-566
Published online on: 01 April 2005

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Article

Adrenomedullin, ANP and BNP are colocalized in a subset of endocrine cells in the rat heart

Anna S. Belloni, Diego Guidolin, Roberta Salmaso, Sergio Bova, Gian Paolo Rossi, Gastone G. Nussdorfer
Pages: 567-571
Published online on: 01 April 2005

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Article

Immunolocalization of platelet glycoprotein IIb/IIIa and P-selectin, and neutrophil - platelet interaction in human coronary unstable plaques

Takeshi Ikuta, Takahiko Naruko, Yoshihiro Ikura, Masahiko Ohsawa, Hiroko Fukushima, Nobuyuki Shirai, Akira Itoh, Kazuo Haze, Shoichi Ehara, Yasuyuki Sasaki, Toshihiko Shibata, Shigefumi Suehiro, Makiko Ueda
Pages: 573-577
Published online on: 01 April 2005

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Article

Human adrenomedullin gene silencing by short interfering RNAs: A preliminary study

Giovanna Albertin, Gianni Carraro, Gastone G. Nussdorfer
Pages: 579-583
Published online on: 01 April 2005

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Article

Down-regulation of DMBT1 gene expression in human oral squamous cell carcinoma

Massao Alberto Imai, Tetsuhiro Moriya, Fabiana Lica Imai, Masashi Shiiba, Hiroki Bukawa, Hidetaka Yokoe, Katsuhiro Uzawa, Hideki Tanzawa
Pages: 585-589
Published online on: 01 April 2005

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Article

Plasma level and tissue expression of angiogenic factors in patients with hereditary hemorrhagic telangiectasia

Haneen Sadick, Ramin Naim, Maliha Sadick, Karl Hörmann, Frank Riedel
Pages: 591-596
Published online on: 01 April 2005

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Article

Status of reduced expression and hypermethylation of the APC tumor suppressor gene in human oral squamous cell carcinoma

Hisako Uesugi, Katsuhiro Uzawa, Kenshi Kawasaki, Ken Shimada, Tetsuhiro Moriya, Akio Tada, Masashi Shiiba, Hideki Tanzawa
Pages: 597-602
Published online on: 01 April 2005

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Article

Protein and mRNA expression levels of VEGF-A and TGF-β1 in different types of human coronary atherosclerotic lesions

Dimitrios Panutsopulos, Efstathios Papalambros, Fragiska Sigala, Alexandros Zafiropoulos, Dimitrios L. Arvanitis, Demetrios A. Spandidos
Pages: 603-610
Published online on: 01 April 2005

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Article

Expression of the gene for hematopoietic cell specific protein is not restricted to cells of hematopoietic origin

Ulrike Fischer, Armin Michel, Eckart U. Meese
Pages: 611-615
Published online on: 01 April 2005

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Article

Amplification and functional characterization of MUC1 promoter and gene-virotherapy via a targeting adenoviral vector expressing hSSTR2 gene in MUC1-positive Panc-1 pancreatic cancer cells in vitro

Limo Chen, Qiang Liu, Renyi Qin, Huangying Le, Ruijuan Xia, Weihua Li, Manoj Kumar
Pages: 617-626
Published online on: 01 April 2005

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Article

Polymorphisms and mutations of the folate receptor-alpha gene and risk of gastric cancer in a Chinese population

Gui Zhang, Qing-Ying Zhang, Xiao-Ping Miao, Dong-Xin Lin, You-Yong Lu
Pages: 627-632
Published online on: 01 April 2005

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Article

Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes

Qun Wang, Alicia Turlington, Stephan Heo, Andrea Blanco, Jian Tian, Zijia Xie, Bingfang Yan, Yinsheng Wan
Pages: 633-640
Published online on: 01 April 2005

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Article

Modulation of the CXC-chemokine expression profile on tumor cells by the immunosuppressive drug mycophenolate mofetil

Tobias Engl, Borna Relja, Iyad Natsheh, Jasmina Makarevic, Iris Müller, Wolf-Dietrich Beecken, Dietger Jonas, Roman A. Blaheta
Pages: 641-647
Published online on: 01 April 2005

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Article

Heat shock protein 90 is required for increased DNA binding activity of activator protein-1, a heterodimer of Fos/JunD, in rheumatoid synovial cells under inflammatory stimuli

Miki Murata, Yasushi Miura, Akira Hashiramoto, Hitomi Kitamura, Hiroki Kawasaki, Kazuko Shiozawa, Shinichi Yoshiya, Hisamitsu Baba, Kazuo Chihara, Shunichi Shiozawa
Pages: 649-653
Published online on: 01 April 2005

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Article

Clinical significance of abnormal lipoprotein patterns in liver diseases

Kinue Ooi, Katsuya Shiraki, Yuko Sakurai, Yoshitska Morishita, Tsutomu Nobori
Pages: 655-660
Published online on: 01 April 2005

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Article

Analysis of the apolipoprotein(a) size polymorphism in patients with systemic lupus erythematosus

Emmanouil Peros, Diego Geroldi, Serena Bugatti, Roberto Caporali, Paola Rossi, Carlomaurizio Montecucco, Angela D'Angelo, Enzo Emanuele
Pages: 661-665
Published online on: 01 April 2005

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Article

Involvement of NF-κB and mitochondrial pathways in docetaxel-induced apoptosis of human oral squamous cell carcinoma

Takahiro Taniguchi, Masato Takahashi, Fumiaki Shinohara, Tomonori Sato, Seishi Echigo, Hidemi Rikiishi
Pages: 667-673
Published online on: 01 April 2005

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Article

β-Cryptoxanthin stimulates cell proliferation and transcriptional activity in osteoblastic MC3T3-E1 cells

Satoshi Uchiyama, Masayoshi Yamaguchi
Pages: 675-681
Published online on: 01 April 2005

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Article

Expression of hTERT mRNA in a mortal liver cell line during S phase without detectable telomerase activity

Kumi Nagao, Junko H. Ohyashiki, Kazuma Ohyashiki, Keiko Tabata, Kenji Takai, Kazuhisa Kameyama, Soichi Kitano, Katsumi Kawano, Nozomu Hibi, Taichi Kanamaru, Hisashi Hisatomi
Pages: 683-688
Published online on: 01 April 2005

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Article

Changes in gene expression level for defense system enzymes against oxidative stress and glutathione level in rat administered paraquat

Masafumi Tomita, Hironobu Katsuyama, Toshiko Okuyama, Kazuo Hidaka, Yohsuke Minatogawa
Pages: 689-693
Published online on: 01 April 2005

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Article

Effects of middle molecular weight fucoidans on in vitro and ex vivo angiogenesis of endothelial cells

Kiminori Matsubara, Changhu Xue, Xue Zhao, Masaharu Mori, Tatsuya Sugawara, Takashi Hirata
Pages: 695-699
Published online on: 01 April 2005

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Review

Vitamin D in normal and pathological parathyroid glands: New prospects for treating hyperparathyroidism (Review)

Pamela Correa Buchwald, Gunnar Westin, Göran Åkerström
Pages: 701-706
Published online on: 01 April 2005

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Article

Ghrelin, peptide YY and their receptors: Gene expression in brain from subjects with and without Prader-Willi syndrome

Zohreh Talebizadeh, Nataliya Kibiryeva, Douglas C. Bittel, Merlin G. Butler
Pages: 707-711
Published online on: 01 April 2005

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Article

Identification of active siRNAs against IGF-IR of porcine coronary smooth muscle cells in a heterologous cell line

Laura Poliseno, Monica Evangelista, Fernanda Ricci, Alessandra Bonotti, Monica Nannipieri, Giuseppe Rainaldi
Pages: 713-718
Published online on: 01 April 2005

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Article

Identification and characterization of a novel human nephronectin gene in silico

Jeffrey T.-J. Huang, Vivian Lee
Pages: 719-724
Published online on: 01 April 2005

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Article

Phosphorylated and hypoacetylated mutant p53 enhances cisplatin-induced apoptosis through caspase-9 pathway in the absence of transcriptional activation or translation

Ming-Derg Lai, Wan-Chi Lin, Yih-Min Sun, Fu-Lin Chang
Pages: 725-734
Published online on: 01 April 2005

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Article

Evaluation of proteasome-inhibitory and apoptosis-inducing potencies of novel (-)-EGCG analogs and their prodrugs

Kristin R. Landis-Piwowar, Deborah J. Kuhn, Sheng Biao Wan, Di Chen, Tak Hang Chan, Q. Ping Dou
Pages: 735-742
Published online on: 01 April 2005

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Article

Comparative genomics on Wnt3 - Wnt9b gene cluster

Masaru Katoh
Pages: 743-747
Published online on: 01 April 2005

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Article

Comparative genomics on Wnt5a and Wnt5b genes

Masuko Katoh, Masaru Katoh
Pages: 749-753
Published online on: 01 April 2005

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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Review Open Access

MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Review Open Access

Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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Review Open Access

MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Article Open Access

Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Review Open Access

Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Review Open Access

Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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Expression of Concern Open Access

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Article

Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Review Open Access

Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Review Open Access

Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Role of vascular smooth muscle cell pathobiology in sepsis‑induced vasoplegia (Review)

Hang Ruan, Xiao-Yan Shen, Shi-Yan Liu, Shu-Sheng Li
Article Number: 87
Published online on: 06 February 2026

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Signalling pathways regulated by FSTL1 in inflammation and potential therapeutic applications (Review)

Changliang Ma, Jingxin Li, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Wencui Li, Zhiqin Deng, Zhe Zhao
Article Number: 86
Published online on: 05 February 2026

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Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling

Qin Deng, Zhongzhong Liu, Qifa Ye, Jia Liu, Zhihui Fu, Xingjian Zhang, Jun Luo, Zhongshan Lu, Pengpeng Yue, Jiansheng Xiao, Qi Xiao
Article Number: 85
Published online on: 05 February 2026

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Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)

Wei Li, Wen-Hong Wang, Yi Song, Xu-Jiong Li, Yan Li, Xia Wang, Ting-Ting Tian, Xiao Huang, Li Zhao
Article Number: 84
Published online on: 04 February 2026

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