Eicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells

  • Authors:
    • L. C.M. Chiu
    • V. E.C. Ooi
    • J. M.F. Wan
  • View Affiliations

  • Published online on: October 1, 2001     https://doi.org/10.3892/ijo.19.4.845
  • Pages: 845-849
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Abstract

Eicosapentaenoic acid (EPA) is a polyunsaturated fatty acid (20:5ω3) found primarily in aquatic organisms. We have shown previously that EPA inhibits the growth but is not toxic to human leukemic K-562 cells. In this study, the anti-proliferative effect of EPA on the leukemic cells was further determined and its impacts on cell cycle progression and cyclin expression were investigated. EPA inhibited proliferation of K-562 cells, which was associated with accumulation of G0/G1 cells and down-regulation of cyclin E expression. Cyclin B1-expressing cells were also reduced showing that down-regulation of cyclin expression might be important in the anti-proliferation of EPA.

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October 2001
Volume 19 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Chiu LC, Ooi VE and Wan JM: Eicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells. Int J Oncol 19: 845-849, 2001.
APA
Chiu, L.C., Ooi, V.E., & Wan, J.M. (2001). Eicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells. International Journal of Oncology, 19, 845-849. https://doi.org/10.3892/ijo.19.4.845
MLA
Chiu, L. C., Ooi, V. E., Wan, J. M."Eicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells". International Journal of Oncology 19.4 (2001): 845-849.
Chicago
Chiu, L. C., Ooi, V. E., Wan, J. M."Eicosapentaenoic acid modulates cyclin expression and arrests cell cycle progression in human leukemic K-562 cells". International Journal of Oncology 19, no. 4 (2001): 845-849. https://doi.org/10.3892/ijo.19.4.845