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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
March-April 2009 Volume 2 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Copy number variation and susceptibility to human disorders (Review)

Barkur S. Shastry
Pages: 143-147
Published online on: 01 March 2009

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Article

Site-specific induction of intestinal hypoxia-inducible factor-1α after hemorrhagic shock

Hiroyuki Nishie, Toru Takahashi, Kazuyoshi Inoue, Hiroko Shimizu, Hiroshi Morimatsu, Yuichiro Toda, Emiko Omori, Reiko Akagi, Hiroshi Katayama, Kiyoshi Morita
Pages: 149-152
Published online on: 01 March 2009

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Article

MEK1 gene mutation in Japanese lung adenocarcinoma patients

Hidefumi Sasaki, Yu Hikosaka, Katsuhiro Okuda, Osamu Kawano, Haruhiro Yukiue, Motoki Yano, Yoshitaka Fujii
Pages: 153-155
Published online on: 01 March 2009

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Article Open Access

Positive emotion-specific changes in the gene expression profile of tickled rats

Miyo Hori, Takashi Hayashi, Yoshimi Nakagawa, Shigeko Sakamoto, Osamu Urayama, Kazuo Murakami
Pages: 157-161
Published online on: 01 March 2009

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Article

Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis

Masahide Matsuyama, Kiyoaki Funao, Yutaka Kawahito, Hajime Sano, Jamel Chargui, Jean-Louis Touraine, Tatsuya Nakatani, Rikio Yoshimura
Pages: 163-167
Published online on: 01 March 2009

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Article

Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma

Qiang Liu, Ling-Jun Song, Wei-Qing Xu, Lei Zhao, Lin Zheng, Zhao-Wen Yan, Guo-Hui Fu
Pages: 169-174
Published online on: 01 March 2009

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Article

Raman spectral signatures of human liver perfusates correlate with oxidation reduction potential

Raphael Bar-Or, Leonard T. Rael, C. Gerald Curtis, Charles W. Mains, Denetta S. Slone, David Bar-Or
Pages: 175-180
Published online on: 01 March 2009

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Article

Activation of the PI3K-AKT pathway in human malignant mesothelioma cells

Yutaro Suzuki, Hideki Murakami, Koji Kawaguchi, Tetsuo Tanigushi, Makiko Fujii, Keiko Shinjo, Yutaka Kondo, Hirotaka Osada, Kaoru Shimokata, Yoshitsugu Horio, Yoshinori Hasegawa, Toyoaki Hida, Yoshitaka Sekido
Pages: 181-188
Published online on: 01 March 2009

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Article

Direct effects of CPT-11 and SN38 on ovarian granulosa cells

Tomoko Utsunomiya, Tetsuji Tanaka, Hirotoshi Utsunomiya, Naohiko Umesaki
Pages: 189-192
Published online on: 01 March 2009

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Article

Telmisartan as a peroxisome proliferator-activated receptor-γ ligand is a new target in the treatment of human renal cell carcinoma

Kiyoaki Funao, Masahide Matsuyama, Yutaka Kawahito, Hajime Sano, Jamel Chargui, Jean-Louis Touraine, Tatsuya Nakatani, Rikio Yoshimura
Pages: 193-198
Published online on: 01 March 2009

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Mitochondrial depolarization and apoptosis associated with sustained activation of c-jun-N-terminal kinasein the human multiple myeloma cell line U266 induced by 2-aminophenoxazine-3-one

Akira Takasaki, Haruo Hanyu, Toshihiko Iwamoto, Ken Shirato, Ryutaro Izumi, Hiroko Toyota, Junichiro Mizuguchi, Keisuke Miyazawa, Akio Tomoda
Pages: 199-203
Published online on: 01 March 2009

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Association of polymorphisms of THBS2 and HSPA8 with hypertension in Japanese individuals with chronic kidney disease

Mitsutoshi Oguri, Kimihiko Kato, Kiyoshi Yokoi, Sachiro Watanabe, Norifumi Metoki, Hidemi Yoshida, Kei Satoh, Yukitoshi Aoyagi, Yutaka Nishigaki, Hideyo Yoshida, Yoshinori Nozawa, Yoshiji Yamada
Pages: 205-211
Published online on: 01 March 2009

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Article

Biphasic effect of short-term pregnancy hormone treatment on N-methyl-N-nitrosourea-induced mammary carcinogenesis in young and old rats

Yen-Chang Lai, Takashi Yuri, Norihisa Uehara, Yoichiro Matsuoka, Sayaka Kanematsu, Airo Tsubura
Pages: 213-220
Published online on: 01 March 2009

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Article

Euphorbiae humifusae induces apoptosis in Hep3B hepatocarcinoma cells via simultaneous activation of the death receptor-mediated and mitochondrial pathways

Sang Ho Seo, Dong Yeok Shin, Su Hyun Hong, Sang Eun Park, Yung Hyun Choi, Sang Hoon Hong
Pages: 221-227
Published online on: 01 March 2009

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Article

Mechanical stress up-regulates RANKL expression via the VEGF autocrine pathway in osteoblastic MC3T3-E1 cells

Takeshi Nakai, Yoshitaka Yoshimura, Yoshiaki Deyama, Kuniaki Suzuki, Junichiro Iida
Pages: 229-234
Published online on: 01 March 2009

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Article

MicroRNA-21 induces cell proliferation and invasion in esophageal squamous cell carcinoma

Yoichiro Mori, Hideyuki Ishiguro, Yoshiyuki Kuwabara, Masahiro Kimura, Akira Mitsui, Ryo Ogawa, Takeyasu Katada, Koshiro Harata, Tatsuya Tanaka, Midori Shiozaki, Yoshitaka Fujii
Pages: 235-239
Published online on: 01 March 2009

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Article

Down-regulation of HOXA4, HOXA7, HOXA10, HOXA11 and MEIS1 during monocyte-macrophage differentiation in THP-1 cells

Vincenzo Martino, Annalisa Bianchera, Laura Reia, Ovidio Bussolati, Raffaella Fazzina, Flora Marino, Luca Montemurro, Roberto Tonelli, Andrea Pession, Gian Carlo Gazzola, Roberto Sala
Pages: 241-244
Published online on: 01 March 2009

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Article

Diallyl trisulfide reverses drug resistance and lowers the ratio of CD133+ cells in conjunction with methotrexate in a human osteosarcoma drug-resistant cell subline

Ji Li, Wei Liu, Kongbo Zhao, Yongkui Zhang, Xin Li, Qiang Yang, Zhenfeng Li, Jianmin Li
Pages: 245-252
Published online on: 01 March 2009

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Article

Increased concentration of plasminogen activator inhibitor-1 and fibrinogen in individuals with metabolic syndrome

Iván G. Palomo, César L. Gutiérrez, Marcelo L. Alarcón, Julio C. Jaramillo, Fabián M. Segovia, Elba M. Leiva, Verónica E. Mujica, Gloria N. Icaza, Nora S. Díaz, Rodrigo Moore-Carrasco
Pages: 253-257
Published online on: 01 March 2009

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Article

Genotype <21CAs/≥21CAs and allele <21CAs of the MANBA gene in melanoma risk and progression in a Swedish population

H. Bu, I. Rosdahl, X.-F. Sun, H. Zhang
Pages: 259-263
Published online on: 01 March 2009

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Article

Is the RET proto-oncogene involved in the pathogenesis of intestinal neuronal dysplasia type B?

Raquel María Fernández, Avencia Sánchez-Mejías, Maria Macarena Ruiz-Ferrer, Manuel López-Alonso, Guillermo Antiñolo, Salud Borrego
Pages: 265-270
Published online on: 01 March 2009

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Article

Betulinic acid does not modulate the activity of P-gp/ABCB1 or MRP1/ABCC1 in a non-tumoral renal cell line: Possible utility in multidrug resistance cancer chemotherapy

João Marcos Delou, Márcia Alves Marques Capella, Cerli Rocha Gattass
Pages: 271-275
Published online on: 01 March 2009

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Article

Common variants of the TLR9 gene influence the clinical course of HBV infection

Nina Jia, Qing Xie, Lanyi Lin, Honglian Gui, Hui Wang, Shan Jiang, Hong Yu, Qing Guo
Pages: 277-281
Published online on: 01 March 2009

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Article

Effect of the methylenetetrahydrofolate reductase gene C677T polymorphism on C-erbB-2 methylation status and its association with cancer

Zhonggan Jin, Qing Lu, Danhong Ge, Ming Zong, Qinghui Zhu
Pages: 283-289
Published online on: 01 March 2009

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Article

MUC1, MUC2 and MUC5AC expression in hepatocellular carcinoma with cardiac metastasis

Yu-Sheng Lin, Shih-Ming Jung, Chun-Nan Yeh, Yung-Chang Chen, Feng-Chun Tsai, Tzu-Fang Shiu, Hsueh-Hua Wu, Pyng-Jing Lin, Pao-Hsien Chu
Pages: 291-294
Published online on: 01 March 2009

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Article

Leptin promotes the immune escape of lung cancer by inducing proinflammatory cytokines and resistance to apoptosis

Yihong Shen, Qing Wang, Qiong Zhao, Jianying Zhou
Pages: 295-299
Published online on: 01 March 2009

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Article

Inhibitory effects of chemically modified heparin on the P-selectin-mediated adhesion of breast cancer cells in vitro

Donghui Mi, Yanguang Gao, Sheng Zheng, Xueqing Ba, Xianlu Zeng
Pages: 301-306
Published online on: 01 March 2009

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Article

Anti-apoptotic effects of pan-caspase inhibitor (Z-VAD), SOD or catalase on antimycin A-induced HeLa cell death

Yong Hwan Han, Suhn Hee Kim, Sung Zoo Kim, Woo Hyun Park
Pages: 307-311
Published online on: 01 March 2009

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Article

Pim-1 activation of cell motility induces the malignant phenotype of tongue carcinoma

Souichi Tanaka, Tetsuya Kitamura, Fumihiro Higashino, Kyoko Hida, Yoichi Ohiro, Mitsunobu Ono, Masanobu Kobayashi, Yasunori Totsuka, Masanobu Shindoh
Pages: 313-318
Published online on: 01 March 2009

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Article

Radiotherapy-induced decreases in substance P levels may potentiate melanoma growth

Aylin Fidan Korcum, Salih Sanlioglu, Gamze Aksu, Nina Tuncel, Nuray Erin
Pages: 319-326
Published online on: 01 March 2009

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Article

Clinical relevance of heparanase mRNA expression in bladder cancer and its usefulness as a detection marker in voided urine

Wei Zhao, Xin-Sheng Wang, Hai-Tao Niu, Li-Li Wang, Bang-Min Han, Shu-Jie Xia
Pages: 327-331
Published online on: 01 March 2009

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Journal Cover
March-2026 Volume 33 Issue 3

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Article

CTRP4 ameliorates dexamethasone‑induced insulin resistance through the IRS‑1/PI3K/AKT pathway in 3T3‑L1 adipocytes

Maireyanmu Rouzi, Xi Sun, Luguang Sheng, Bilin Xu, Tao Lei, Jun Lu, Jie Gao
Article Number: 101
Published online on: 27 January 2026

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Article Open Access

PTUPB, a soluble epoxide hydrolase/cyclooxygenase‑2 dual inhibitor, reduces endothelial‑to‑mesenchymal transition and improves doxorubicin‑induced vascular and cardiac toxicity

Hevna Dhulkifle, Lubna Therachiyil, Maram H. Hasan, Shahd M. Younis, Nizar A. Al‑Shar'i, Huseyin C. Yalcin, Zaid H. Maayah
Article Number: 100
Published online on: 27 January 2026

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Retraction Open Access

[Retracted] miR‑367 enhances the proliferation and invasion of cutaneous malignant melanoma by regulating phosphatase and tensin homolog expression

Jianwen Long, Jing Luo, Xuwen Yin
Article Number: 99
Published online on: 26 January 2026

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Review Open Access

Advances in the mechanisms of the NLRP3 inflammasome in sepsis‑induced cardiomyopathy and targeted therapeutic studies 
(Review)

Yifei Chen, Zhaohui Zhang, Gaosheng Zhou
Article Number: 98
Published online on: 22 January 2026

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Article Open Access

HMGN2 induces pyroptosis in tumour cells by modulating the STT3B/PD‑L1/caspase‑1/GSDMD axis

Wenwen Han, Hongli Chen, Bomiao Cui, Jiao Chen, Ping Zhang, Yun Feng
Article Number: 97
Published online on: 22 January 2026

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Article Open Access

Naringin ameliorates intestinal injury in ulcerative colitis model mice by modulating the JAK2/STAT3 signaling pathway

Miaomiao Wu, Yating An, Yongmin Li, Wei He, Ying Wang, Yaqi Wang, Caixia Wu
Article Number: 96
Published online on: 22 January 2026

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Review

PDX1 in human cancers: Molecular mechanisms, dual roles and clinical implications (Review)

Chen Zhou, Yifei Wang, Jie Zhao, Yantao Yang, Yuhang Yuan, Xiaochen Hou, Yu Tang, Lianhua Ye
Article Number: 95
Published online on: 22 January 2026

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Retraction Open Access

[Retracted] Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species

Uddin Md Nazim, Honghua Yin, Sang-Youel Park
Article Number: 94
Published online on: 19 January 2026

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Review Open Access

Converting ‘cold’ to ‘hot’ hepatocellular carcinoma for improved immunotherapy (Review)

Ching-Hua Hsieh, Pei-Chin Chuang
Article Number: 93
Published online on: 15 January 2026

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Article Open Access

Pathological mechanism of ferroptosis in a rat model of α‑naphthyl isothiocyanate‑induced chronic cholestasis

Zhen Guo, Jiaxuan Wang, Yiwen Wang, Xinzhu Liu, Yubing Xia, Ping Liu, Li Qi, Jia Liu, Xiaoning Wang
Article Number: 92
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] Role of hypoxia‑inducible factor‑1α and CD146 in epidermal growth factor receptor‑mediated angiogenesis in salivary gland adenoid cystic carcinom

Wei-Ming Wang, Zhi-Li Zhao, Wen-Feng Zhang, Yi-Fang Zhao, Lu Zhang, Zhi-Jun Sun
Article Number: 91
Published online on: 13 January 2026

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Review Open Access

Klebsiella pneumoniae and pyogenic liver abscess: Emerging clinical threats, virulence mechanisms and therapeutic strategies (Review)

Gulam Mustafa Hasan, Taj Mohammad, Sobia Zaidi, Anas Shamsi, Sukhwinder Singh Sohal, Md. Imtaiyaz Hassan
Article Number: 90
Published online on: 13 January 2026

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Article Open Access

Collagen III regulates the termination of liver regeneration by suppressing hepatocyte proliferation and promoting functional recovery

Haiyang Peng, Zhiyong Chen, Qiwei Zhang, Yuezhou Zhang, Peng Yang, Jianping Gong, Andong Zhao
Article Number: 89
Published online on: 13 January 2026

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Review Open Access

Application of extracellular vesicles in the diagnosis and treatment of chronic obstructive pulmonary disease (Review)

Yixin Zhang, Tong Ren, Jianbo Xue, Yan Yu, Xianqiang Zhou, Xiaoyi Hu, Wenyi Yu, Zhancheng Gao, Cuiling Feng
Article Number: 88
Published online on: 13 January 2026

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Article Open Access

Cigarette smoke combined with Klebsiella pneumoniae induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway

Yange Tian, Kexin Xu, Ruilong Lu, Kangchen Li, Xuejie Shao, Yixi Liao, Yakun Zhao, Zhiguang Qiu, Haoran Dong, Xuefang Liu
Article Number: 87
Published online on: 12 January 2026

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Retraction Open Access

[Retracted] 8‑bromo‑7‑methoxychrysin induces apoptosis by regulating Akt/FOXO3a pathway in cisplatin‑sensitive and resistant ovarian cancer cells

Qing Ding, Yi Chen, Qing Zhang, Yanling Guo, Zhi Huang, Liqing Dai, Sudan Cao
Article Number: 86
Published online on: 12 January 2026

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Article Open Access

Anxiety‑induced overactive bladder: The role of oxidative stress and NF‑κB signaling pathway with Hsp90 as a potential biomarker

Zhipeng Zhou, Lina Xu, Han Wu, Huaishan Hong
Article Number: 85
Published online on: 12 January 2026

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Article Open Access

Echinacoside alleviates asthenozoospermia by upregulating Sox5‑mediated transcriptional activation of the CatSper gene

Zi-Run Jin, Yong-Wei Huo, Bo-Heng Liu, Hong Tian, Shuo Yuan, Yue Tian, Ke Xi, Jie Cai, Hui Jiang, Yong Jiang, Guo-Gang Xing
Article Number: 84
Published online on: 12 January 2026

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Article Open Access

Artemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in mice with osteoporosis via the Nrf2/Slc7a11/Gpx4 pathway

Pei Li, Xinyu Wan, Wenjie Li, Ding Cheng, Ying Yang, Yuhan Wang, Ruyuan Zhu, Yanjing Chen, Haixia Liu, Zhiguo Zhang
Article Number: 83
Published online on: 12 January 2026

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Review Open Access

Prolyl hydroxylase domain proteins: Localization, regulation, function and their role in erythropoiesis (Review)

Yan Hou, Zhao-Hua Zhang, Wen-Qian Li, Guo-Xiong Han, Kuo Shen, You-Bang Xie
Article Number: 82
Published online on: 12 January 2026

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Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review)

Bing-Yu Liang, Zi-Yue Fu, Fen-Fen Li, Ping-Ting Zhou, Zi-Hui Xie, Ke Han, Yan-Xun Han, Shan-Wen Chen, Yi Zhao, Hai-Feng Pan, Ye-Hai Liu, Yu-Chen Liu
Article Number: 81
Published online on: 07 January 2026

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Review Open Access

Interleukin‑6 and ischemic stroke: From mechanisms to clinical prospects (Review)

Xinyue Wang, Xiaohang Zhang, Jianing Lin, Ping Lin
Article Number: 80
Published online on: 05 January 2026

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Article Open Access

Preliminary exploration of the putative function of SF3A2 in clear cell renal cell carcinoma

Ru Chen, Jie Xu
Article Number: 79
Published online on: 05 January 2026

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Retraction Open Access

[Retracted] TIPE‑2 suppresses growth and aggressiveness of hepatocellular carcinoma cells through downregulation of the phosphoinositide 3‑kinase/AKT signaling pathway

Lin Wang, Chen Chen, Shuzhi Feng, Jianli Tian
Article Number: 78
Published online on: 05 January 2026

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Journal Cover
April-2026 Volume 33 Issue 4

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Circular RNAs in intervertebral disc degeneration: Current insights into mechanisms and therapeutic potentials (Review)

Luyan Wang, Ke Yang, Houjun Zhu, Dachuan Wang, Feng Wang, Xianfa Du
Article Number: 111
Published online on: 05 February 2026

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Review Open Access

T‑cadherin and its impact on human diseases (Review)

Yan Song, Xinyi Wang, Yunfei Bian
Article Number: 110
Published online on: 05 February 2026

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Review

CD20 monoclonal antibody‑rituximab for the treatment of diffuse alveolar hemorrhage in children (Review)

Xiaobo Zhang, Xiao Wu, Yan Li, Guangmin Nong
Article Number: 109
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