Rapid bone repair in a patient with lung cancer metastases to the spine using a novel herbal medicine: A case report

  • Authors:
    • Rong Pu
    • Qianhong Zhao
    • Zhimei Li
    • Lingyan Zhang
    • Xiaolu Luo
    • Yangji Zeren
    • Cui Yu
    • Xianyong Li
  • View Affiliations

  • Published online on: July 18, 2016     https://doi.org/10.3892/ol.2016.4879
  • Pages: 2023-2027
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Abstract

The prognosis of lung carcinoma with metastasis to the bone, particularly to the spine, is poor. Chemotherapy and radiotherapy are established treatments for metastatic bone disease, but their effectiveness is unsatisfactory and bone repair following their use is slow and difficult. Medicine prepared from herbal extracts may be an alternative treatment option. The present study discusses the case of a 59-year-old patient diagnosed with squamous cell lung cancer (T2N3M1) in which first‑line chemotherapy using docetaxel plus cisplatin failed. Heavy multiple bone metastases were detected in the T9 vertebra and sixth left rib, resulting in a high risk of pathological fracture. Eastern Cooperative Oncology Group (ECOG) and numerical rating scale (NRS) scores of pain were 2 and 4, respectively. A second-line treatment was chosen consisting of biological intracontrol treatment (BICT) plus bisphosphonates administered over 40 days. BICT is a therapy involving the use of herbal extracts (including ginseng, herba agrimoniae, hairyvein agrimonia herb, white flower patrinia herb and arginine) and palliative care. A partial positive response was reached following use of this regimen, particularly with regard to bone repair. A computed tomography scan revealed a 90% reduction in the broken area of the rib cage and T9 vertebra. The bone repair was rapid and almost complete. In addition, growth of the primary tumor in the right pulmonary hilar and metastasis in the mediastinal lymph nodes were stabilized following treatment. ECOG and NRS scores were decreased to 1 and 0, respectively, leading to an improved quality of life. Based on these results, the present study suggests that this herbal medicine‑based regimen promotes bone repair and inhibits tumor growth, with low toxicity. However, the mechanism by which herbal medicine promotes rapid bone repair is unclear. Further studies are required to determine whether cells in the tumor microenvironment are stimulated to undergo re‑differentiation by unidentified herbal substances.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Pu R, Zhao Q, Li Z, Zhang L, Luo X, Zeren Y, Yu C and Li X: Rapid bone repair in a patient with lung cancer metastases to the spine using a novel herbal medicine: A case report. Oncol Lett 12: 2023-2027, 2016
APA
Pu, R., Zhao, Q., Li, Z., Zhang, L., Luo, X., Zeren, Y. ... Li, X. (2016). Rapid bone repair in a patient with lung cancer metastases to the spine using a novel herbal medicine: A case report. Oncology Letters, 12, 2023-2027. https://doi.org/10.3892/ol.2016.4879
MLA
Pu, R., Zhao, Q., Li, Z., Zhang, L., Luo, X., Zeren, Y., Yu, C., Li, X."Rapid bone repair in a patient with lung cancer metastases to the spine using a novel herbal medicine: A case report". Oncology Letters 12.3 (2016): 2023-2027.
Chicago
Pu, R., Zhao, Q., Li, Z., Zhang, L., Luo, X., Zeren, Y., Yu, C., Li, X."Rapid bone repair in a patient with lung cancer metastases to the spine using a novel herbal medicine: A case report". Oncology Letters 12, no. 3 (2016): 2023-2027. https://doi.org/10.3892/ol.2016.4879