Open Access

KDM3A is not associated with metastasis and prognosis of breast cancer

  • Authors:
    • Juan Yao
    • Shutao Zheng
    • Baiyan Li
    • Xinxin Li
    • Wenya Liu
  • View Affiliations

  • Published online on: April 25, 2018     https://doi.org/10.3892/ol.2018.8578
  • Pages: 9751-9756
  • Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lysine demethylase 3A (KDM3A), also known as JMJD1A, has been associated with metastasis and poor prognosis in several cancer types, including renal cell carcinoma, prostate cancer and Ewing sarcoma. However, little is known regarding the clinicopathological significance of KDM3A expression in breast cancer (BCa). To investigate the clinical relevance of KDM3A expression in the setting of BCa, immunohistochemistry was performed on a tissue microarray consisting of 150 commercially available BCa samples. No significant correlation was identified between KDM3A expression and various clinicopathological variables, including clinical stage, pathological grade, tumor size and the expression statuses of human epidermal growth factor receptor 2, estrogen receptor, and progesterone receptor. In addition, no significant association between KDM3A expression and overall prognosis was observed. Taken together, these findings suggest that there is no significant association between KDM3A expression and clinicopathological variables, indicating that KDM3A may not be associated with the malignant behavior of BCa.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yao J, Zheng S, Li B, Li X and Liu W: KDM3A is not associated with metastasis and prognosis of breast cancer. Oncol Lett 15: 9751-9756, 2018.
APA
Yao, J., Zheng, S., Li, B., Li, X., & Liu, W. (2018). KDM3A is not associated with metastasis and prognosis of breast cancer. Oncology Letters, 15, 9751-9756. https://doi.org/10.3892/ol.2018.8578
MLA
Yao, J., Zheng, S., Li, B., Li, X., Liu, W."KDM3A is not associated with metastasis and prognosis of breast cancer". Oncology Letters 15.6 (2018): 9751-9756.
Chicago
Yao, J., Zheng, S., Li, B., Li, X., Liu, W."KDM3A is not associated with metastasis and prognosis of breast cancer". Oncology Letters 15, no. 6 (2018): 9751-9756. https://doi.org/10.3892/ol.2018.8578