Silencing of Forkhead box D1 inhibits proliferation and migration in glioma cells

  • Authors:
    • Yuan-Feng Gao
    • Tao Zhu
    • Xiao-Yuan Mao
    • Chen-Xue Mao
    • Ling Li
    • Ji-Ye Yin
    • Hong-Hao Zhou
    • Zhao-Qian Liu
  • View Affiliations

  • Published online on: January 2, 2017     https://doi.org/10.3892/or.2017.5344
  • Pages: 1196-1202
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Despite the extensive role of Forkhead box transcription factors in the development and progression of various cancers, little is known about their role in glioma. We examined the expression and function of Forkhead box D1 (FOXD1) in glioma cell behavior and found that FOXD1 was upregulated and directly correlated with the glioma grade. Data analysis also revealed significant differences in FOXD1 expression for both gene expression profiles (GSE4290 and GSE7696) and the TCGA datasets. Additionally, decreased FOXD1 expression in U251 and U87 glioma cells caused a delay in cell growth and a disruption in colony formation. FOXD1 silencing also promoted generation of apoptotic bodies containing nuclear fragments. Cells with suppressed expression of FOXD1 markedly reduced glioma cell migration. Our results suggest that FOXD1 may serve as a novel regulator of glioblastoma cell behavior that may offer a novel target for gene targeted glioma therapies.
View Figures
View References

Related Articles

Journal Cover

February-2017
Volume 37 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gao Y, Zhu T, Mao X, Mao C, Li L, Yin J, Zhou H and Liu Z: Silencing of Forkhead box D1 inhibits proliferation and migration in glioma cells. Oncol Rep 37: 1196-1202, 2017
APA
Gao, Y., Zhu, T., Mao, X., Mao, C., Li, L., Yin, J. ... Liu, Z. (2017). Silencing of Forkhead box D1 inhibits proliferation and migration in glioma cells. Oncology Reports, 37, 1196-1202. https://doi.org/10.3892/or.2017.5344
MLA
Gao, Y., Zhu, T., Mao, X., Mao, C., Li, L., Yin, J., Zhou, H., Liu, Z."Silencing of Forkhead box D1 inhibits proliferation and migration in glioma cells". Oncology Reports 37.2 (2017): 1196-1202.
Chicago
Gao, Y., Zhu, T., Mao, X., Mao, C., Li, L., Yin, J., Zhou, H., Liu, Z."Silencing of Forkhead box D1 inhibits proliferation and migration in glioma cells". Oncology Reports 37, no. 2 (2017): 1196-1202. https://doi.org/10.3892/or.2017.5344