Chaenomeles speciosa: A review of chemistry and pharmacology
- Authors:
- Shu‑Ya Zhang
- Li‑Ya Han
- Hong Zhang
- Hai‑Liang Xin
-
Affiliations: Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Department of Biochemistry and Molecular Biology, Ningxia Medical University, Yinchuan, Ningxia, P.R. China, Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, P.R. China, Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China - Published online on: November 1, 2013 https://doi.org/10.3892/br.2013.193
- Pages: 12-18
This article is mentioned in:
Abstract
Chinese Pharmacopeia Commission, . Chinese Pharmacopoeia. Chinese Medicine and Technology Publishing House; Beijing: pp. 572010 | |
Zhonghua Bencao Editorial Group, . Zhonghua Bencao (Chinese Herbal Medicine). 4. Shanghai Science and Technology Publishing House; Shanghai: pp. 112–120. 1999 | |
Nanjing University of Traditional Chinese Medicine, . Dictionary of Traditional Chinese Medicine. Shanghai Science and Technology Publishing House; Shanghai: pp. 349–350. 2006 | |
He SM and Jiang J: Review on TCM treatment of migraine and tension-type headache. Chin Arch Tradit Chin Med. 24:1469–1471. 2006. | |
Wang LZ: Therapy of apoplectic sequelae by six schemes. Henan Tradit Chin Med. 26:31–32. 2006. | |
An CP and Cheng W: Review on mechanisms and symptoms of depression in TCM (Traditional Chinese Medicine). Inf Tradit Chin Med. 24:12–14. 2007. | |
Zhang H, Geng YL, Wang DJ, Liu JH, Wang X, Du JH and Li SB: Research on nutrient components of different species of Chaenomeles speciosa Nakai. Shandong Sci. 24:24–27. 2011. | |
Chen Q and Wei W: Effects and mechanisms of glucosides of Chaenomeles speciosa on collagen-induced arthritis in rats. Int Immunopharmacol. 3:593–608. 2003.PubMed/NCBI | |
Dai M, Wei W, Shen YX and Zheng YQ: Glucosides of Chaenomeles speciosa remit rat adjuvant arthritis by inhibiting synoviocyte activities. Acta Pharmacol Sin. 24:1161–1166. 2003. | |
Wang NP, Dai M, Wang H, Zhang LL and Wei W: Antinociceptive effect of glucosides of Chaenomeles speciosa. Chin J Pharmacol Toxicol. 19:169–174. 2005. | |
Kong JS and Yang XH: Mechanisms analysis on the analgesic effect of total flavonoids extracted from Chaenomeles lagenaria. Lishizhen Med Mater Med Res. 20:549–550. 2009. | |
Li X, Yang YB, Yang Q, Sun LN and Chen WS: Anti-inflammatory and analgesic activities of Chaenomeles speciosa fractions in laboratory animals. J Med Food. 12:1016–1022. 2009. View Article : Google Scholar | |
Yang XH, Wu J and Guo LJ: Anti-inflammatory activity of saponin in Chaenomeles speciosa in rat adjuvant arthritis. Lishizhen Med Mater Med Res. 21:2833–2834. 2010. | |
Li SG and Chen Y: Effect of Chaenomeles speciosa polysaccharide on adjuvant arthritis in mice and its mechanisms. Chin J Exp Trad Med Form. 17:159–162. 2011. | |
Price KR, Johnson IT and Fenwick GR: The chemistry and biological significance of saponins in foods and feedingstuffs. Crit Rev Food Sci Nutr. 26:27–135. 1987. View Article : Google Scholar : PubMed/NCBI | |
Mahato SB, Sarkar SK and Poddar G: Triterpenoid saponins. Phytochemistry. 27:3037–3067. 1988. View Article : Google Scholar | |
Hasmeda M, Kweifio-Okai G, Macrides T and Polya GM: Selective inhibition of eukaryote protein kinases by anti-inflammatory triterpenoids. Planta Med. 65:14–18. 1999. View Article : Google Scholar : PubMed/NCBI | |
Salminen A, Lehtonen M, Suuronen T, Kaarniranta K and Huuskonen J: Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential. Cell Mol Life Sci. 65:2979–2999. 2008. View Article : Google Scholar : PubMed/NCBI | |
Singh GB, Singh S, Bani S, Gupta BD and Banerjee SK: Anti-inflammatory activity of oleanolic acid in rats and mice. J Pharm Pharmacol. 44:456–458. 1992. View Article : Google Scholar : PubMed/NCBI | |
Kapil A and Sharma S: Effect of oleanolic acid on complement in adjuvant- and carrageenan-induced inflammation in rats. J Pharm Pharmacol. 47:585–587. 1995. View Article : Google Scholar : PubMed/NCBI | |
Nataraju A, Raghavendra Gowda CD, Rajesh R and Vishwanath BS: Group IIA secretory PLA2 inhibition by ursolic acid: a potent anti-inflammatory molecule. Curr Top Med Chem. 7:801–809. 2007. View Article : Google Scholar : PubMed/NCBI | |
Dharmappa KK, Kumar RV, Nataraju A, Mohamed R, Shivaprasad HV and Vishwanath BS: Anti-inflammatory activity of oleanolic acid by inhibition of secretory phospholipase A2. Planta Med. 75:211–215. 2009. View Article : Google Scholar : PubMed/NCBI | |
Ahmad SF, Khan B, Bani S, Suri KA, Satti NK and Qazi GN: Amelioration of adjuvant-induced arthritis by ursolic acid through altered Th1/Th2 cytokine production. Pharmacol Res. 53:233–240. 2006. View Article : Google Scholar : PubMed/NCBI | |
Takada K, Nakane T, Masuda K and Ishii H: Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-alpha-induced E-selectin expression by cultured umbilical vein endothelial cells. Phytomedicine. 17:1114–1119. 2010. View Article : Google Scholar : PubMed/NCBI | |
Yoon JJ, Lee YJ, Kim JS, Kang DG and Lee HS: Protective role of betulinic acid on TNF-alpha-induced cell adhesion molecules in vascular endothelial cells. Biochem Biophys Res Commun. 391:96–101. 2010. View Article : Google Scholar : PubMed/NCBI | |
Hsum YW, Yew WT, Hong PL, et al: Cancer chemopreventive activity of maslinic acid: suppression of COX-2 expression and inhibition of NF-kappaB and AP-1 activation in Raji cells. Planta Med. 77:152–157. 2011. View Article : Google Scholar : PubMed/NCBI | |
Chen Y, Wei W, Wu H, Tang LQ, Wang XY and Yang YQ: Down-regulation effect of glucosides of Chaenomeles speciosa on the levels of serum antibodies in rats with adjuvant arthritis. Chin Pharmacol Bull. 23:941–944. 2007.(In Chinese). | |
Yang XH, Wu J and Guo LJ: Optimization on extraction technology of saponin of Chaenomeles speciosa and study on its anti-inflammatory immunologic mechanism to rat adjuvant arthritis. West China J Pharm Sci. 25:49–51. 2010. | |
Zhang L, Cheng YX, Liu AL, Wang HD, Wang YL and Du GH: Antioxidant, anti-inflammatory and anti-influenza properties of components from Chaenomeles speciosa. Molecules. 15:8507–8517. 2010. View Article : Google Scholar : PubMed/NCBI | |
Chen JC, Chang YS, Wu SL, et al: Inhibition of Escherichia coli heat-labile enterotoxin-induced diarrhea by Chaenomeles speciosa. J Ethnopharmacol. 113:233–239. 2007. | |
Xie XF, Cai XQ, Zhu SY and Zou GL: Chemical composition and antimicrobial activity of essential oils of Chaenomeles speciosa from China. Food Chem. 100:1312–1315. 2007. View Article : Google Scholar | |
Yu Q, Bai ZC, Meng DS, Lu LC, Fu RQ and Zhang XM: Antibacterial effects of 23 kinds of Chinese herbal medicine extracts on Streptococcus pneumoniae. China Pharm. 22:2135–2136. 2011. | |
Lee KT, Kim BJ, Kim JH, Heo MY and Kim HP: Biological screening of 100 plant extracts for cosmetic use (I): inhibitory activities of tyrosinase and DOPA auto-oxidation. Int J Cosmet Sci. 19:291–298. 1997. View Article : Google Scholar : PubMed/NCBI | |
Tang Y, Yu Xp, Mi MT, Zhao J, Wang J and Zhang T: Antioxidative property and antiatherosclerotic effects of the powder processed from Chaenomeles speciosa in APOE−/−mice. J Food Biochem. 34:535–548. 2010. | |
Liu ZX, Hu SD, Zou K, Pan JR and Liao QB: Studies on antioxidation in vitro of ethanol extract from Chaenomeles speciosa(Sweet) Nakai. J China Three Gorges Univ (Nat Sci). 30:72–75. 2008.(In Chinese). | |
Zheng YQ, Wei W, Dai M and Wang NP: Glucosides of Chaenomeles speciosa suppressed contact hypersensitivity response via modulating the thymus T lymphocytes subsets in mice. Chin Pharmacol Bull. 20:1016–1019. 2004.(In Chinese). | |
Shi JJ, Liu CQ, Li B, et al: Protecting effect of Chaenomeles speciosa broth on immunosuppressive mice induced by cyclophosphamide. J Chin Med Mater. 32:1418–1421. 2009.(In Chinese). | |
Zhao G, Jiang ZH, Zheng XW, Zang SY and Guo LH: Dopamine transporter inhibitory and antiparkinsonian effect of common flowering quince extract. Pharmacol Biochem Behav. 90:363–371. 2008. View Article : Google Scholar : PubMed/NCBI | |
Milic M, Bao X, Rizos D, Liu F and Ziegler MG: Literature review and pilot studies of the effect of QT correction formulas on reported β2-agonist-induced QTc prolongation. Clin Ther. 28:582–590. 2006.PubMed/NCBI | |
Wang H, Li SY, Zhao CK and Zeng X: A system for screening agonists targeting β2-adrenoceptor from Chinese medicinal herbs. J Zhejiang Univ Sci B. 10:243–250. 2009. | |
Liu W, Yang XH, Zhou M and Li CD: Pharmacodynamical mechanisms of total flavonoids from Chaenomeles lagenaria Koidz in the relaxation of gastrointestinal smooth muscles. World Chin J Digestol. 15:165–167. 2007. | |
Wang HX: Lab study of effects fructus Chaenomeles on protecting hepar and decreasing enzyme. World J Integr Tradit West Med. 2:213–215. 2007. | |
Li B, Liu CQ, Shi JJ, et al: Preventive effect of Chaenomeles fruits on non-alcoholic steatohepatitis in mice. Food Sci. 31:258–261. 2010. | |
Liu HJ, Hu JH, Sun LN, Cai Z, Shi J and Liu T: Inhibition effects of oleanolic acid from Chaenomeles lagenaria on hepatitis B virus in vitro. Pharm J Chin People’s Liberation Army. 18:272–274. 2002. | |
Liu J, Liu Y and Klaassen CD: Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice. Acta Pharmacologica Sinica. 16:97–102. 1995.PubMed/NCBI | |
Reisman SA, Aleksunes LM and Klaassen CD: Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Biochem Pharmacol. 77:1273–1282. 2009. View Article : Google Scholar : PubMed/NCBI | |
Liu J, Wu Q, Lu YF and Pi J: New insights into generalized hepatoprotective effects of oleanolic acid: key roles of metallothionein and Nrf2 induction. Biochem Pharmacol. 76:922–928. 2008. View Article : Google Scholar : PubMed/NCBI | |
Jin ZR: The extract of antitumor active ingredients in Chaenomeles speciosa. Chin Tradit Herb Drug Commun. 6:181975. | |
Laszczyk MN: Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy. Planta Med. 75:1549–1560. 2009. View Article : Google Scholar : PubMed/NCBI | |
Kuttan G, Pratheeshkumar P, Manu KA and Kuttan R: Inhibition of tumor progression by naturally occurring terpenoids. Pharm Biol. 49:995–1007. 2011. View Article : Google Scholar : PubMed/NCBI | |
Chu R, Zhao X, Griffin C, et al: Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cells by BN107 and oleanolic acid. Int J Cancer. 127:1209–1219. 2010. View Article : Google Scholar : PubMed/NCBI | |
Zhou R, Zhang Z, Zhao L, et al: Inhibition of mTOR signaling by oleanolic acid contributes to its anti-tumor activity in osteosarcoma cells. J Orthop Res. 29:846–852. 2011. View Article : Google Scholar : PubMed/NCBI | |
Shyu MH, Kao TC and Yen GC: Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP. J Agric Food Chem. 58:6110–6118. 2010. View Article : Google Scholar | |
Lin CC, Huang CY, Mong MC, Chan CY and Yin MC: Antiangiogenic potential of three triterpenic acids in human liver cancer cells. J Agric Food Chem. 59:755–762. 2011. View Article : Google Scholar : PubMed/NCBI | |
Lucio KA, da Rocha GG, Moncao-Ribeiro LC, Fernandes J, Takiya CM and Gattass CR: Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo. PLoS One. 6:e285962011. View Article : Google Scholar : PubMed/NCBI | |
Liu J: Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol. 49:57–68. 1995. View Article : Google Scholar : PubMed/NCBI | |
Liu J: Oleanolic acid and ursolic acid: research perspectives. J Ethnopharmacol. 100:92–94. 2005. View Article : Google Scholar : PubMed/NCBI | |
Kong JS, Yang XH and Liu W: The relaxant effects and related mechanism of total flavones from Chaenomeles lagenaria Koidz on gastrointestinal smooth muscles. Lishizhen Med Mater Med Res. 18:2123–2124. 2007. | |
Wang X, Jia W, Zhao A and Wang X: Anti-influenza agents from plants and traditional Chinese medicine. Phytother Res. 20:335–341. 2006. View Article : Google Scholar : PubMed/NCBI | |
Luo JF: The isolation and identification of oleanolic acid in Chaenomeles speciosa. Chin Tradit Herb Drug. 4:481983. | |
Yin B, Yan HG, He B, et al: An orthogonal experiment to optimize refluxing extraction of oleanolic acid in leaves of Chaenomeles speciosa s. nakai. Food Sci Technol. 31:101–103. 2006. | |
Chen HC, Ding LS, Peng SL and Liao X: Study on the chemical constituents in Chaenomeles speciosa. Chin Tradit Herb Drugs. 36:30–31. 2005. | |
Guo XM, Zhang L, Quan SC, Hong YF, Sun LN and Liu MZ: The isolation and identification of triterpenoids in Chaenomeles speciosa. J Chin Med Mater. 23:546–547. 1998. | |
Song YL, Zhang L, Gao JM, Du GH and Cheng YX: Speciosaperoxide, a new triterpene acid, and other terpenoids from Chaenomeles speciosa. J Asian Nat Prod Res. 10:214–217. 2008. View Article : Google Scholar | |
Yin K, Gao HY, Li XN and Wu LJ: Chemical constituents of Chaenomeles speciosa(Sweet) Nakai. J Shenyang Pharm Univ. 23:760–763. 2006. | |
Yang YB, Yang Y, Li X, et al: Studies on the chemical constituents of Chaenomeles speciosa. J Chin Med Mater. 32:1388–1390. 2009.(In Chinese). | |
Gong FJ, Chen L, Lu XC and Wang YW: Determination of organic acid components from fruits of Chaenomeles speciosa by GC-MS. J Plant Resour Environ. 14:55–56. 582005. | |
Gao CW, Kan Y, Lei ZM, Duan ZH, et al: The studies on the acidic constituents in the fresh- fruit of Chaenomeles speciosa. J Yunnan Univ. 21:319–321. 1999. | |
Song YL, Feng ZB, Cheng YX and Gao JM: Chemical components of Chaenomeles speciosa(Sweet) Nakai. Acta Bot Boreali Occident Sin. 27:831–833. 2007. | |
Tang Q, Song SW, Chen HW, Huang B and Song LH: Determination of the Rutin in Chaenomeles speciosa S. Nakai by HPLC. J Xuzhou I Technol. 22:65–67. 2007. | |
Horvat RJ, Chapman GW Jr and Payne JA: Volatiles of ripe flowering quince (Chaenomeles speciosa Nakai). J Essent Oil Res. 6:81–83. 1994. View Article : Google Scholar |