Exercise improves high fat diet-impaired vascular function

Fang,Jun; Tang,Mei

doi:10.3892/br.2017.972

Exercise improves high fat diet-impaired vascular function

Authors:
- Jun Fang
- Mei Tang
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Affiliations: Division of Nephrology, Department of Internal Medicine, Xianning Central Hospital and The First Clinical Hospital of Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Infusion Preparation Center of the Pharmacy Department, Xianning Central Hospital and The First Clinical Hospital of Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China
Published online on: August 25, 2017 https://doi.org/10.3892/br.2017.972
Pages: 337-342

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Abstract

The prevalence of metabolic syndrome and cardiovascular disease is increasing due to increases in the consumption of high fat diets (HFDs) and the epidemic of obesity. In the present study, it was hypothesized that swimming exercise may prevent HFD-induced impairment of aortic function and that these changes are associated with reduction of oxidative stress, proinflammatory adipokines/cytokines. Male, 6-week-old C57BL/6J mice were fed a 60% lipid composition HFD with or without swimming exercise (90 min/swim and 2 swims/day) for 16 weeks. Exercise training prevented HFD-induced increases in visceral fat weight, total cholesterol and triglycerides. Furthermore, exercise training improved HFD-impaired aortic endothelium-dependent dilation that was associated with reduction of oxidative stress, leptin, resistin, monocyte chemoattractant protein 1, interleukin (IL)6 and IL8. In addition, exercise inhibited HFD-induced vascular endothelial growth factor expression in gastrocnemius skeletal muscle. These data demonstrate that swimming exercise prevents aortic tissue oxidative stress, inflammation and vascular dysfunction in HFD-induced obesity.

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1	Ramalho L, da Jornada MN, Antunes LC and Hidalgo MP: Metabolic disturbances due to a high-fat diet in a non-insulin-resistant animal model. Nutr Diabetes. 7:e2452017. View Article : Google Scholar : PubMed/NCBI
2	Huang S, Liu H, Meng N, Li B and Wang J: Hypolipidemic and Antioxidant effects of Malus toringoides (Rehd.) hughes leaves in high-fat-diet-induced hyperlipidemic rats. J Med Food. 20:258–264. 2017. View Article : Google Scholar : PubMed/NCBI
3	Lim S and Meigs JB: Links between ectopic fat and vascular disease in humans. Arterioscler Thromb Vasc Biol. 34:1820–1826. 2014. View Article : Google Scholar : PubMed/NCBI
4	Townsend RR: Arterial stiffness: Recommendations and Standardization. Pulse Basel. 4 Suppl 1:3–7. 2017. View Article : Google Scholar : PubMed/NCBI
5	Yamaguchi R, Yamamoto T, Sakamoto A, Ishimaru Y, Narahara S, Sugiuchi H and Yamaguchi Y: Chemokine profiles of human visceral adipocytes from cryopreserved preadipocytes: Neutrophil activation and induction of nuclear factor-kappa B repressing factor. Life Sci. 143:225–230. 2015. View Article : Google Scholar : PubMed/NCBI
6	Selcuk A, Bulucu F, Kalafat F, Cakar M, Demirbas S, Karaman M, Ay SA, Saglam K, Balta S, Demirkol S, et al: Skinfold thickness as a predictor of arterial stiffness: Obesity and fatness linked to higher stiffness measurements in hypertensive patients. Clin Exp Hypertens. 35:459–464. 2013. View Article : Google Scholar : PubMed/NCBI
7	Park SY, Rossman MJ, Gifford JR, Bharath LP, Bauersachs J, Richardson RS, Abel ED, Symons JD and Riehle C: Exercise training improves vascular mitochondrial function. Am J Physiol Heart Circ Physiol. 310:H821–H829. 2016.PubMed/NCBI
8	Morishima T, Restaino RM, Walsh LK, Kanaley JA, Fadel PJ and Padilla J: Prolonged sitting-induced leg endothelial dysfunction is prevented by fidgeting. Am J Physiol Heart Circ Physiol. 311:H177–H182. 2016. View Article : Google Scholar : PubMed/NCBI
9	Li YY, Shi ZM, Yu XY, Feng P and Wang XJ: Urotensin II-induced insulin resistance is mediated by NADPH oxidase-derived reactive oxygen species in HepG2 cells. World J Gastroenterol. 22:5769–5779. 2016. View Article : Google Scholar : PubMed/NCBI
10	Yan Q, Liu Q, Zweier JL and Liu X: Potency of authentic nitric oxide in inducing aortic relaxation. Pharmacol Res. 55:329–334. 2007. View Article : Google Scholar : PubMed/NCBI
11	Tang M and Fang J: TNF-α regulates apoptosis of human vascular smooth muscle cells through gap junctions. Mol Med Rep. 15:1407–1411. 2017. View Article : Google Scholar : PubMed/NCBI
12	Zhang FL, Xing YQ, Wu YH, Liu HY, Luo Y, Sun MS, Guo ZN and Yang Y: The prevalence, awareness, treatment, and control of dyslipidemia in northeast China: A population-based cross-sectional survey. Lipids Health Dis. 16:612017. View Article : Google Scholar : PubMed/NCBI
13	Raj M: Obesity and cardiovascular risk in children and adolescents. Indian J Endocrinol Metab. 16:13–19. 2012. View Article : Google Scholar : PubMed/NCBI
14	Yamashita T, Kawashima S, Ohashi Y, Ozaki M, Rikitake Y, Inoue N, Hirata K, Akita H and Yokoyama M: Mechanisms of reduced nitric oxide/cGMP-mediated vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. Hypertension. 36:97–102. 2000. View Article : Google Scholar : PubMed/NCBI
15	Rodriguez-Pascual F, Miras-Portugal MT and Torres M: Effect of cyclic GMP-increasing agents nitric oxide and C-type natriuretic peptide on bovine chromaffin cell function: Inhibitory role mediated by cyclic GMP-dependent protein kinase. Mol Pharmacol. 49:1058–1070. 1996.PubMed/NCBI
16	Rios FJ, Neves KB, Nguyen Dinh Cat A, Even S, Palacios R, Montezano AC and Touyz RM: Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes. J Pharmacol Exp Ther. 353:27–34. 2015. View Article : Google Scholar : PubMed/NCBI
17	Keaney JF Jr, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Massaro JM, Sutherland P, Vita JA and Benjamin EJ: Framingham Study: Obesity and systemic oxidative stress: Clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol. 23:434–439. 2003. View Article : Google Scholar : PubMed/NCBI
18	Csányi G and Miller FJ Jr: Oxidative stress in cardiovascular disease. Int J Mol Sci. 15:6002–6008. 2014. View Article : Google Scholar : PubMed/NCBI
19	Rocha M, Apostolova N, Hernandez-Mijares A, Herance R and Victor VM: Oxidative stress and endothelial dysfunction in cardiovascular disease: Mitochondria-targeted therapeutics. Curr Med Chem. 17:3827–3841. 2010. View Article : Google Scholar : PubMed/NCBI
20	Lozano I, Van der Werf R, Bietiger W, Seyfritz E, Peronet C, Pinget M, Jeandidier N, Maillard E, Marchioni E, Sigrist S, et al: High-fructose and high-fat diet-induced disorders in rats: Impact on diabetes risk, hepatic and vascular complications. Nutr Metab (Lond). 13:152016. View Article : Google Scholar : PubMed/NCBI
21	Guo X, Li J, Tang R, Zhang G, Zeng H, Wood RJ and Liu Z: High fat diet alters gut microbiota and the expression of paneth cell-antimicrobial peptides preceding changes of circulating inflammatory cytokines. Mediators Inflamm. 2017:94748962017. View Article : Google Scholar : PubMed/NCBI
22	Wong A, Sanchez-Gonzalez M, Kalfon R, Alvarez-Alvarado S and Figueroa A: The effects of stretching training on cardiac autonomic function in obese postmenopausal women. Altern Ther Health Med. 23:20–26. 2017.PubMed/NCBI
23	Toyama K, Sugiyama S, Oka H, Hamada M, Iwasaki Y, Horio E, Rokutanda T, Nakamura S, Spin JM, Tsao PS, et al: A pilot study: The beneficial effects of combined statin-exercise therapy on cognitive function in patients with coronary artery disease and mild cognitive decline. Intern Med. 56:641–649. 2017. View Article : Google Scholar : PubMed/NCBI
24	Onat A: Metabolic syndrome: Nature, therapeutic solutions and options. Expert Opin Pharmacother. 12:1887–1900. 2011. View Article : Google Scholar : PubMed/NCBI
25	Szostak J and Laurant P: The forgotten face of regular physical exercise: A ‘natural’ anti-atherogenic activity. Clin Sci (Lond). 121:91–106. 2011. View Article : Google Scholar : PubMed/NCBI
26	Peeri M and Amiri S: Protective effects of exercise in metabolic disorders are mediated by inhibition of mitochondrial-derived sterile inflammation. Med Hypotheses. 85:707–709. 2015. View Article : Google Scholar : PubMed/NCBI
27	Silvennoinen M, Rinnankoski-Tuikka R, Vuento M, Hulmi JJ, Torvinen S, Lehti M, Kivelä R and Kainulainen H: High-fat feeding induces angiogenesis in skeletal muscle and activates angiogenic pathways in capillaries. Angiogenesis. 16:297–307. 2013. View Article : Google Scholar : PubMed/NCBI