Open Access

Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p

  • Authors:
    • Ying Dong
    • Ting Zhang
    • Shengwen Shao
    • Xining Li
    • Peiyu Jiang
    • Yue Guo
    • Donghua Gu
  • View Affiliations

  • Published online on: August 23, 2023     https://doi.org/10.3892/br.2023.1651
  • Article Number: 69
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer (BC) has become a threat to women's health. In addition, patients with triple‑negative BC (TNBC) have the worst prognosis among all patients with BC. Furthermore, long non‑coding RNA ABHD11‑AS1 is aberrantly highly expressed in TNBC, suggesting that RNA ABHD11‑AS1 may serve as an important role in the progression of TNBC. However, the detailed function of ABHD11‑AS1 in TNBC remains largely unknown. The levels of ABHD11‑AS1 in MDA‑MB‑231 cells were assessed by reverse transcription‑quantitative PCR. To investigate the effect of ABHD11‑AS1 on the progression of TNBC, a xenograft animal model was established. Knockdown of ABHD11‑AS1 inhibited the epithelial‑mesenchymal transition and migration of TNBC cells. In addition, ABHD11‑AS1 promoted the viability and migration of TNBC cells by upregulating microRNA (miR)‑199a‑5p. Furthermore, knockdown of ABHD11‑AS1 suppressed TNBC tumor growth in vivo by upregulating miR‑199a‑5p. In conclusion, knockdown of ABHD11‑AS1 suppressed the progression of TNBC via upregulation of miR‑199a‑5p. The data of the present study may provide novel directions and a theoretical basis for TNBC treatment.
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October-2023
Volume 19 Issue 4

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Dong Y, Zhang T, Shao S, Li X, Jiang P, Guo Y and Gu D: Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p. Biomed Rep 19: 69, 2023.
APA
Dong, Y., Zhang, T., Shao, S., Li, X., Jiang, P., Guo, Y., & Gu, D. (2023). Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p. Biomedical Reports, 19, 69. https://doi.org/10.3892/br.2023.1651
MLA
Dong, Y., Zhang, T., Shao, S., Li, X., Jiang, P., Guo, Y., Gu, D."Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p". Biomedical Reports 19.4 (2023): 69.
Chicago
Dong, Y., Zhang, T., Shao, S., Li, X., Jiang, P., Guo, Y., Gu, D."Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p". Biomedical Reports 19, no. 4 (2023): 69. https://doi.org/10.3892/br.2023.1651