Progress in the study of association between hematological indicators and retinopathy of prematurity (Review)

Tang,Wenwen; Zhang,Yin; Zhang,Haifang; Li,Kejun; Zhao,Zhihua; Ma,Huijie; Jiang,Xinli; Jia,Zhiyang; Ma,Qingmin

doi:10.3892/br.2024.1799

Progress in the study of association between hematological indicators and retinopathy of prematurity (Review)

Authors:
- Wenwen Tang
- Yin Zhang
- Haifang Zhang
- Kejun Li
- Zhihua Zhao
- Huijie Ma
- Xinli Jiang
- Zhiyang Jia
- Qingmin Ma
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Affiliations: Department of Ophthalmology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China, Department of Physiology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China, Department of Ophthalmology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China
Published online on: June 6, 2024 https://doi.org/10.3892/br.2024.1799
Article Number: 111
Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Retinopathy of prematurity (ROP) is a retinopathy caused by abnormal proliferation of blood vessels in premature infants. It can lead to retinal detachment and, in severe cases, blindness, rendering ROP a critical condition. Advances in neonatal medicine have improved survival rates of low birth weight and low gestational age infants. However, this progress has also led to a rise in incidence of ROP. Currently, premature birth, low birth weight and high postpartum oxygen levels are independent risk factors for ROP. Other factors include mode of delivery, multiple births, anemia, blood transfusion, maternal pregnancy factors, neonatal bronchopulmonary dysplasia, use of surfactants, arterial ductus arteriosus and necrotizing enterocolitis. Laboratory indicators in premature infants such as platelet count, levels of blood glucose, inflammatory cells, lipid and hemoglobin and blood transfusion may also be associated with ROP. However, the etiology and pathogenesis of ROP are not fully understood. A number of factors may influence the onset and progression of ROP, including decreased platelet counts, decreased hemoglobin levels, increased white blood cell counts, increased blood glucose levels, and disorders of lipid metabolism. The present study reviewed the effects of platelet count, hemoglobin, blood glucose, inflammatory cells and factors, blood lipids, and plasma metabolic pathways on ROP.

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