Open Access

Proton pump inhibitor use is associated with increased liver steatosis

  • Authors:
    • Hongsheng Yu
    • Mingkai Li
    • Bilan Yang
    • Huiying Sun
    • Hao Jiang
    • Zixi Liang
    • Abdukyamu Smayi
    • Bin Wu
    • Yidong Yang
  • View Affiliations

  • Published online on: June 13, 2024     https://doi.org/10.3892/br.2024.1804
  • Article Number: 116
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Despite proton pump inhibitors (PPIs) being generally safe, there are questions about their potential long‑term complications. The present study aimed to investigate the association between PPI therapy and the incidence of hepatic steatosis and liver fibrosis in the outpatient population of the United States. The present study included 7,395 individuals aged ≥20 years who underwent hepatic vibration‑controlled transient elastography (VCTE) examination. The data were obtained from the January 2017 to March 2020 pre‑pandemic National Health and Nutrition Examination Survey. Among the 7,395 adults who were included (mean age, 50.59 years; 3,656 male), 9.8% were prescribed PPIs. Following multivariable adjustment, the use of PPIs was significantly associated with hepatic steatosis [odds ratio (OR), 1.25; 95% confidence interval (CI), 1.02‑1.53]. Prolonged use of PPIs was found to increase the risk of developing hepatic steatosis over time (P=0.006). Sensitivity analyses using different definitions of hepatic steatosis, such as a controlled attenuation parameter ≥285 dB/m (OR, 1.19; CI, 1.01‑1.40), non‑alcoholic fatty liver disease (OR, 1.50; 95% CI, 1.16‑1.93) and metabolic dysfunction‑associated steatotic liver disease (OR, 1.26; 95% CI, 1.05‑1.52), consistently demonstrated an association between PPI prescription and hepatic steatosis. The administration of PPI therapy was linked with hepatic steatosis in US adults, although no significant association was observed with liver stiffness, as determined by VCTE.
View Figures
View References

Related Articles

Journal Cover

August-2024
Volume 21 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yu H, Li M, Yang B, Sun H, Jiang H, Liang Z, Smayi A, Wu B and Yang Y: Proton pump inhibitor use is associated with increased liver steatosis. Biomed Rep 21: 116, 2024
APA
Yu, H., Li, M., Yang, B., Sun, H., Jiang, H., Liang, Z. ... Yang, Y. (2024). Proton pump inhibitor use is associated with increased liver steatosis. Biomedical Reports, 21, 116. https://doi.org/10.3892/br.2024.1804
MLA
Yu, H., Li, M., Yang, B., Sun, H., Jiang, H., Liang, Z., Smayi, A., Wu, B., Yang, Y."Proton pump inhibitor use is associated with increased liver steatosis". Biomedical Reports 21.2 (2024): 116.
Chicago
Yu, H., Li, M., Yang, B., Sun, H., Jiang, H., Liang, Z., Smayi, A., Wu, B., Yang, Y."Proton pump inhibitor use is associated with increased liver steatosis". Biomedical Reports 21, no. 2 (2024): 116. https://doi.org/10.3892/br.2024.1804