Open Access

Oxidative stress and acute pancreatitis (Review)

  • Authors:
    • Yongxia Cai
    • Feng Yang
    • Xizhu Huang
  • View Affiliations

  • Published online on: June 27, 2024     https://doi.org/10.3892/br.2024.1812
  • Article Number: 124
  • Copyright : © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Acute pancreatitis (AP) is a common inflammatory disorder of the exocrine pancreas that causes severe morbidity and mortality. Although the pathophysiology of AP is poorly understood, a substantial body of evidence suggests some critical events for this disease, such as dysregulation of digestive enzyme production, cytoplasmic vacuolization, acinar cell death, edema formation, and inflammatory cell infiltration into the pancreas. Oxidative stress plays a role in the acute inflammatory response. The present review clarified the role of oxidative stress in the occurrence and development of AP by introducing oxidative stress to disrupt cellular Ca2+ balance and stimulating transcription factor activation and excessive release of inflammatory mediators for the application of antioxidant adjuvant therapy in the treatment of AP.
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August-2024
Volume 21 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Cai Y, Yang F and Huang X: Oxidative stress and acute pancreatitis (Review). Biomed Rep 21: 124, 2024
APA
Cai, Y., Yang, F., & Huang, X. (2024). Oxidative stress and acute pancreatitis (Review). Biomedical Reports, 21, 124. https://doi.org/10.3892/br.2024.1812
MLA
Cai, Y., Yang, F., Huang, X."Oxidative stress and acute pancreatitis (Review)". Biomedical Reports 21.2 (2024): 124.
Chicago
Cai, Y., Yang, F., Huang, X."Oxidative stress and acute pancreatitis (Review)". Biomedical Reports 21, no. 2 (2024): 124. https://doi.org/10.3892/br.2024.1812