Diagnosis and treatment challenges in a rare Clostridium infection: A case report
- Authors:
- Bianca Bălaș‑Maftei
- Carmen-Elena Florea
- Maria Obreja
- Alexandra Rotaru
- Larisa Miftode
- Egidia Miftode
- Erika-Raluca Irimie‑Băluță
- Carmen Manciuc
View Affiliations
Affiliations: Doctoral School, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 00115 Iași, Romania, Department of Infectious Diseases, ‘Sf. Parascheva’ Clinical Hospital of Infectious Diseases, 700116 Iași, Romania
- Published online on: August 19, 2024 https://doi.org/10.3892/br.2024.1837
-
Article Number:
149
-
Copyright: © Bălaș‑Maftei
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
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Abstract
The Clostridium genus includes >180 species of Gram‑positive, anaerobic, sporulating bacteria. Under certain conditions, these can cause a wide range of invasive infections in humans. Clostridium paraputrificum occurs in the commensal intestinal flora and related bacteremia typically occurs secondary to an injury to the intestinal mucosa and in the presence of predisposing conditions, such as gastrointestinal disorders, malignancies, diabetes, HIV infection or neutropenia. The current study presents the case of a 70‑year‑old male patient, a rural resident living in poverty, with a history of alchohol consumption and cardiovascular pathology. Several initial and subsequent diagnoses were ruled out by successive investigations (e.g., stroke, meningitis, localized tetanus). Blood cultures were eventually found positive for Clostridium paraputrificum and the patient developed septic shock despite treatment with metronidazole and penicillin G. Once switched to carbapenem, the patient progressed favorably, suggesting that carbapenem could work as a first‑line antibiotic treatment for Clostridium paraputrificum infections.
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