Open Access

Advances in ferroptosis in head and neck cancer (Review)

  • Authors:
    • Xinyi Wang
    • Kunpeng Li
    • Teng Song
    • Suliang Xing
    • Wei Wang
    • Yuhui Fang
  • View Affiliations

  • Published online on: August 20, 2024     https://doi.org/10.3892/br.2024.1839
  • Article Number: 151
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ferroptosis is an iron‑dependent form of cell death that was discovered in 2012. It encompasses the coordinated orchestration of three fundamental biological pathways: Iron homeostasis, glutathione regulation and lipid metabolism. Head and neck cancer (HNC) is a heterogeneous group of cancers occurring on the mucosal surfaces of the upper respiratory and digestive tracts. Head and neck squamous cell carcinoma is the most common type of HNC, accounting for >90% of HNC cases, and has high morbidity and mortality rates. Despite improvements in diagnosis and treatment, the 5‑year survival rate hovers at a dismal 50‑60%, with recurrence afflicting nearly 30% of patients, highlighting the inadequacies of currently available treatments. Of note, research exploring the nexus between ferroptosis and HNC remains scarce; however, the present review endeavors to synthesize current knowledge surrounding ferroptosis. The present review elaborated on the normal physiological role of ferroptosis and discussed its potential involvement in HNC pathogenesis. Therapeutic strategies and prognostic paradigms for HNC that target ferroptosis were also reviewed. This review aims to provide direction to catalyze future investigations into ferroptosis in HNC.
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November-2024
Volume 21 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Wang X, Li K, Song T, Xing S, Wang W and Fang Y: Advances in ferroptosis in head and neck cancer (Review). Biomed Rep 21: 151, 2024.
APA
Wang, X., Li, K., Song, T., Xing, S., Wang, W., & Fang, Y. (2024). Advances in ferroptosis in head and neck cancer (Review). Biomedical Reports, 21, 151. https://doi.org/10.3892/br.2024.1839
MLA
Wang, X., Li, K., Song, T., Xing, S., Wang, W., Fang, Y."Advances in ferroptosis in head and neck cancer (Review)". Biomedical Reports 21.5 (2024): 151.
Chicago
Wang, X., Li, K., Song, T., Xing, S., Wang, W., Fang, Y."Advances in ferroptosis in head and neck cancer (Review)". Biomedical Reports 21, no. 5 (2024): 151. https://doi.org/10.3892/br.2024.1839