Open Access

Biological variation of capillary blood glucose: A systematic review

  • Authors:
    • Kenia D. Zanette
    • Flavia Martinello
  • View Affiliations

  • Published online on: October 30, 2024     https://doi.org/10.3892/br.2024.1885
  • Article Number: 7
  • Copyright: © Zanette et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Biological variation (BV) refers to changes in biochemical constituents in the blood or other biological fluids, indicative of body regulation via homeostatic processes. Intra‑ and interindividual BV data are essential for establishing analytical performance specifications and evaluating the significance between consecutive measurements of an analyte. Given this context, the present study conducted a systematic review of the intra‑ and interindividual BV of capillary blood glucose. Out of 461 initial studies identified, only 4 met the inclusion criteria for detailed analysis after excluding 419 for title irrelevance, 10 for duplication, 21 based on abstract content and 7 based on article content. Notably, none of the studies primarily focused on the intra‑ and interindividual BV of capillary blood glucose; rather, they reported it as a secondary outcome. Regarding fasting, data analyses revealed intra‑individual BVs of 4.5 and 31.1% for healthy and diabetic individuals, respectively, and interindividual coefficient of variations of 4.7‑5.8 and 12.9‑16.3% for healthy and diabetic individuals, respectively. Only one study provided the analytical coefficient of variation, corroborating the recommended practices. Additionally, the fasting duration, meal standardization before sampling, and number and interval between collections varied among the studies. Hence, the results suggest that there are no reliable data on intra‑ and interindividual BVs for capillary blood glucose in the literature.
View Figures
View References

Related Articles

Journal Cover

January-2025
Volume 22 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zanette KD and Martinello F: Biological variation of capillary blood glucose: A systematic review. Biomed Rep 22: 7, 2025.
APA
Zanette, K.D., & Martinello, F. (2025). Biological variation of capillary blood glucose: A systematic review. Biomedical Reports, 22, 7. https://doi.org/10.3892/br.2024.1885
MLA
Zanette, K. D., Martinello, F."Biological variation of capillary blood glucose: A systematic review". Biomedical Reports 22.1 (2025): 7.
Chicago
Zanette, K. D., Martinello, F."Biological variation of capillary blood glucose: A systematic review". Biomedical Reports 22, no. 1 (2025): 7. https://doi.org/10.3892/br.2024.1885