Open Access

Network pharmacology analysis and clinical verification of Panax notoginseng saponins in deep venous thrombosis prevention

  • Authors:
    • Bin Yan
    • Yachan Ning
    • Julong Guo
    • Limin Liu
    • Chunmei Wang
  • View Affiliations

  • Published online on: November 1, 2024     https://doi.org/10.3892/br.2024.1886
  • Article Number: 8
  • Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the present study, the mechanism of Panax notoginseng saponins (PNS), the extract of Panax notoginseng, against deep vein thrombosis (DVT) was explored by networks pharmacology and its effect was demonstrated through clinical data. PNS includes 5 main active components, which have 101 targets. A total of 1,342 DVT‑related targets were obtained, 55 of which were the common targets of PNS and DVT. AKT1, TNF, IL1B, EGFR, VEGFA and MAPK3 were selected as hub genes from the protein‑protein interaction network. The potential anti‑DVT mechanism of PNS may involve the AGE‑RAGE signaling pathway and the PI3K‑Akt signaling pathway. Molecular docking presented a total of 10 binding interactions, with all molecules showing good binding ability with PNS‑DVT common hub target genes (all binding energy <‑6 kcal/mol). Analysis of clinical data showed that the combined use of PNS significantly reduced the incidence of postoperative DVT in patients undergoing orthopedic surgery compared with the use of low‑molecular‑weight heparin alone, which is the most commonly used clinical anticoagulant.
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January-2025
Volume 22 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Yan B, Ning Y, Guo J, Liu L and Wang C: Network pharmacology analysis and clinical verification of <em>Panax notoginseng</em> saponins in deep venous thrombosis prevention. Biomed Rep 22: 8, 2025.
APA
Yan, B., Ning, Y., Guo, J., Liu, L., & Wang, C. (2025). Network pharmacology analysis and clinical verification of <em>Panax notoginseng</em> saponins in deep venous thrombosis prevention. Biomedical Reports, 22, 8. https://doi.org/10.3892/br.2024.1886
MLA
Yan, B., Ning, Y., Guo, J., Liu, L., Wang, C."Network pharmacology analysis and clinical verification of <em>Panax notoginseng</em> saponins in deep venous thrombosis prevention". Biomedical Reports 22.1 (2025): 8.
Chicago
Yan, B., Ning, Y., Guo, J., Liu, L., Wang, C."Network pharmacology analysis and clinical verification of <em>Panax notoginseng</em> saponins in deep venous thrombosis prevention". Biomedical Reports 22, no. 1 (2025): 8. https://doi.org/10.3892/br.2024.1886