Open Access

Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review)

  • Authors:
    • Jiarui Li
    • Mingxiu Sun
    • Ming Tang
    • Xin Song
    • Kaize Zheng
    • Tianwei Meng
    • Chengjia Li
    • Likun Du
  • View Affiliations

  • Published online on: December 27, 2024     https://doi.org/10.3892/br.2024.1918
  • Article Number: 40
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Obesity is a pervasive global health challenge that substantially reduces the quality of life of millions of individuals and impedes social and economic advancement. Obesity is an independent risk factor that contributes to a range of chronic non‑communicable metabolic diseases, significantly affecting energy metabolism, mental health, cancer susceptibility, sleep quality, and other physiological processes. The PI3K/AKT signaling pathway, a significant glucose, lipid, and protein metabolism regulator, is integral to cellular growth, survival, and apoptosis. Apoptosis is a highly regulated form of programmed cell death that is critical for immune cell maturation and tissue repair. The present review examines the association between obesity, the PI3K/AKT pathway, and mitochondrial apoptosis to elucidate the potential mechanisms by which obesity may activate apoptotic pathways. These findings provide a theoretical foundation for mitigating obesity‑related complications by targeting these critical pathways.
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March-2025
Volume 22 Issue 3

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Copy and paste a formatted citation
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Spandidos Publications style
Li J, Sun M, Tang M, Song X, Zheng K, Meng T, Li C and Du L: Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review). Biomed Rep 22: 40, 2025.
APA
Li, J., Sun, M., Tang, M., Song, X., Zheng, K., Meng, T. ... Du, L. (2025). Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review). Biomedical Reports, 22, 40. https://doi.org/10.3892/br.2024.1918
MLA
Li, J., Sun, M., Tang, M., Song, X., Zheng, K., Meng, T., Li, C., Du, L."Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review)". Biomedical Reports 22.3 (2025): 40.
Chicago
Li, J., Sun, M., Tang, M., Song, X., Zheng, K., Meng, T., Li, C., Du, L."Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review)". Biomedical Reports 22, no. 3 (2025): 40. https://doi.org/10.3892/br.2024.1918