Effect of kidney‑reinforcing and marrow‑beneficial Chinese medicine on bone metabolism‑related factors following spinal cord injury in rats

  • Authors:
    • Da‑An Zhou
    • Yue Ning Deng
    • Lei Liu
    • Jian Jun Li
  • View Affiliations

  • Published online on: April 27, 2016     https://doi.org/10.3892/etm.2016.3304
  • Pages: 485-491
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Abstract

The present study aimed to investigate the effect of traditional Chinese kidney reinforcing and marrow-beneficial medicine (KRMB) on the prevention and treatment of abnormal bone metabolism and osteoporosis (OP) resulting from spinal cord injury (SCI). Rat models of OP following SCI were surgically established. The rats were randomly divided into five groups: Normal; sham operation + KRMB; normal + KRMB; SCI + KRMB; and SCI model group. Bone mineral density (BMD), and the expression of bone gamma‑carboxyglutamic‑acid containing protein (BGP), hepcidin mRNA and bone sialoprotein (BSP) were recorded at 1, 2, 4, 6, 8 and 10 weeks after the operation. BMD expression in the SCI model group was significantly lower compared with the normal, sham + KRMB and normal + KRMB groups at 4, 6, 8 and 10 weeks (P<0.01), and was significantly lower than that in the SCI + KRMB group at 6 (P<0.05), 8 and 10 weeks (P<0.01). The level of serum BGP in the SCI model group was significantly higher compared with the normal, sham + KRMB and normal + KRMB groups at each time point (P<0.01), and lower than the SCI + KRMB group (P<0.01). The SCI + KRMB group was significantly higher than the normal, sham operation + KRMB and normal + KRMB groups (P<0.01). Hepcidin mRNA expression in the rat livers in the normal, sham + KRMB and normal + KRMB group was significantly higher than that in the SCI + KRMB group and SCI model group at each time point (P<0.01). Hepcidin mRNA expression in the SCI + KRMB group was significantly higher than that in the SCI model group at 1 week (P<0.01), and significantly higher than the SCI model group at 2, 4, 6 ,8 and 10 weeks (P<0.01). BSP expression in the SCI model group was significantly higher than that in the normal, sham + KRMB and normal + KRMB groups at each time point (P<0.01). BSP expression in SCI model group was higher than that in the SCI + KRMB group at 1 (P<0.05), 2, 4, 6, 8 and 10 weeks (P<0.01). In conclusion, KRMB traditional Chinese medicine may have a curative effect on secondary OP resulting from SCI.
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July-2016
Volume 12 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhou DA, Deng YN, Liu L and Li JJ: Effect of kidney‑reinforcing and marrow‑beneficial Chinese medicine on bone metabolism‑related factors following spinal cord injury in rats. Exp Ther Med 12: 485-491, 2016.
APA
Zhou, D., Deng, Y.N., Liu, L., & Li, J.J. (2016). Effect of kidney‑reinforcing and marrow‑beneficial Chinese medicine on bone metabolism‑related factors following spinal cord injury in rats. Experimental and Therapeutic Medicine, 12, 485-491. https://doi.org/10.3892/etm.2016.3304
MLA
Zhou, D., Deng, Y. N., Liu, L., Li, J. J."Effect of kidney‑reinforcing and marrow‑beneficial Chinese medicine on bone metabolism‑related factors following spinal cord injury in rats". Experimental and Therapeutic Medicine 12.1 (2016): 485-491.
Chicago
Zhou, D., Deng, Y. N., Liu, L., Li, J. J."Effect of kidney‑reinforcing and marrow‑beneficial Chinese medicine on bone metabolism‑related factors following spinal cord injury in rats". Experimental and Therapeutic Medicine 12, no. 1 (2016): 485-491. https://doi.org/10.3892/etm.2016.3304