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Garlic oil suppresses high‑fat diet induced obesity in rats through the upregulation of UCP‑1 and the enhancement of energy expenditure

  • Authors:
    • Yuki Kagawa
    • Yori Ozaki‑Masuzawa
    • Takashi Hosono
    • Taiichiro Seki

  • View Affiliations

  • Published online on: December 27, 2019     https://doi.org/10.3892/etm.2019.8386
  • Pages: 1536-1540

  • Copyright: © Kagawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Garlic (Allium sativum L.) has long been used as a medicinal food. Indeed, garlic and its constituents have been shown to possess potent regulatory activities in bodily functions, including blood coagulation, lipid metabolism, immunity and xenobiotic metabolism. In this study, we aimed to examine the anti‑obesity effects of garlic oil and to elucidate the possible underlying mechanisms. For this purpose, garlic oil (GO; 80 mg/kg body weight, p.o.) or corn oil alone as a vehicle‑control were administered to male Sprague‑Dawley rats every other day for 10 weeks. The results revealed that GO administration significantly reduced body weight gain and white adipose tissue (WAT) mass, which had been increased by feeding on the AIN‑76‑based high‑fat diet (60% kcal fat). Expired gas analysis was performed at 9 weeks following the GO administration to calculate fuel oxidation. GO administration enhanced O2 consumption during the dark period (at night) and increased energy expenditure through fat oxidation during the light period (daytime); however, carbohydrate oxidation remained unaltered. Western blot analysis revealed that GO administration increased UCP1 protein expression in brown adipose tissue (BAT). On the whole, the findings of this study indicated that GO suppressed body weight gain and WAT mass in the rat model of high‑fat diet‑induced obesity by increasing UCP1 expression and by enhancing fat oxidation and energy expenditure.
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February-2020
Volume 19 Issue 2

Print ISSN: 1792-0981
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Spandidos Publications style
Kagawa Y, Ozaki‑Masuzawa Y, Hosono T and Seki T: Garlic oil suppresses high‑fat diet induced obesity in rats through the upregulation of UCP‑1 and the enhancement of energy expenditure. Exp Ther Med 19: 1536-1540, 2020.
APA
Kagawa, Y., Ozaki‑Masuzawa, Y., Hosono, T., & Seki, T. (2020). Garlic oil suppresses high‑fat diet induced obesity in rats through the upregulation of UCP‑1 and the enhancement of energy expenditure. Experimental and Therapeutic Medicine, 19, 1536-1540. https://doi.org/10.3892/etm.2019.8386
MLA
Kagawa, Y., Ozaki‑Masuzawa, Y., Hosono, T., Seki, T."Garlic oil suppresses high‑fat diet induced obesity in rats through the upregulation of UCP‑1 and the enhancement of energy expenditure". Experimental and Therapeutic Medicine 19.2 (2020): 1536-1540.
Chicago
Kagawa, Y., Ozaki‑Masuzawa, Y., Hosono, T., Seki, T."Garlic oil suppresses high‑fat diet induced obesity in rats through the upregulation of UCP‑1 and the enhancement of energy expenditure". Experimental and Therapeutic Medicine 19, no. 2 (2020): 1536-1540. https://doi.org/10.3892/etm.2019.8386