Diagnostic values of NLR and miR‑141 in patients with osteoarthritis and their association with severity of knee osteoarthritis

Cai,Chengchen; Zhang,Ruojing; Xu,Xiaoli; Li,Guowen; Gou,Haixin

doi:10.3892/etm.2020.9506

Diagnostic values of NLR and miR‑141 in patients with osteoarthritis and their association with severity of knee osteoarthritis

Authors:
- Chengchen Cai
- Ruojing Zhang
- Xiaoli Xu
- Guowen Li
- Haixin Gou
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Affiliations: Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Scientific Research, Shanghai TCM‑Integrated Hospital, Shanghai University of TCM, Shanghai 200082, P.R. China
Published online on: November 25, 2020 https://doi.org/10.3892/etm.2020.9506
Article Number: 74
Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to explore the diagnostic values of neutrophil‑lymphocyte ratio (NLR) and microRNA (miR)‑141 in patients with osteoarthritis and their association with the severity of knee osteoarthritis. In total 142 patients with osteoarthritis (the study group) admitted to Shanghai TCM‑Integrated Hospital, Shanghai University of TCM from January 2017 to January 2019 and 150 healthy controls (the control group) were enrolled in the present study. NLR and miR‑141 in peripheral blood and their diagnostic values for osteoarthritis were compared between the two groups. The two indicators in the study group were significantly increased (P<0.001), and their combined detection had a better diagnostic value for the disease (P<0.001). Moreover, they were closely associated to the progression of the disease and were independent risk factors (P<0.001). To sum up, NLR and miR‑141 were significantly increased in the peripheral blood of patients with osteoarthritis. Their combined detection exhibited a good diagnostic value for the disease and may become a potential therapeutic target osteoarthritis in the future.

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