Open Access

Comparison of fertility outcomes between oil‑based
and water‑based contrast media during hysterosalpingography: A meta‑analysis

  • Authors:
    • Jun Chen
    • Shushu Liu
    • Jianguo Lu
  • View Affiliations

  • Published online on: August 3, 2023     https://doi.org/10.3892/etm.2023.12148
  • Article Number: 449
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Water‑based and oil‑based contrast media are both widely used in clinical practice for patients receiving hysterosalpingography (HSG). However, minor controversy exists about whether the oil‑based contrast medium has a superior fertility‑enhancing effect during HSG. The present meta‑analysis intended to comprehensively compare the fertility outcomes of patients receiving either an oil‑based or a water‑based contrast medium during HSG. Web of Science, PubMed, Excerpta Medica Database, Cochrane, China National Knowledge Infrastructure, Wanfang Data and China Science and Technology Journal Database were examined for literature comparing the fertility enhancement between oil‑based and water‑based contrast media during HSG up to November 10, 2022 and there was no cut off for studies published earlier than any given year. Data for clinical pregnancy, ongoing pregnancy, live birth, miscarriage and ectopic pregnancy were extracted and analyzed. A total of 11 studies with 2,462 patients receiving oil‑based contrast medium and 2,830 patients receiving water‑based contrast medium during HSG were included. Relative risks (RRs) and 95% confidence intervals (CIs) were presented for outcome assessment, and the random effects model was utilized for all analyses. Publication bias was analyzed using Egger's and Begg's tests. The results indicated that the rate of clinical pregnancy was increased using oil‑based contrast medium compared with water‑based contrast medium [relative risk (RR) (95% CI), 1.29 (1.07, 1.54); P=0.006]. In addition, the rate of ongoing pregnancy [RR (95% CI), 1.39 (1.22, 1.59); P<0.001] and live birth [RR (95% CI), 1.41 (1.07, 1.87); P=0.016] were also increased using oil‑based contrast medium compared with water‑based contrast medium. However, miscarriage [RR (95% CI), 1.06 (0.61, 1.86); P=0.833] and ectopic pregnancy [RR (95% CI), 0.66 (0.18, 2.36); P=0.518] were not affected by using oil‑based or water‑based contrast medium. Begg's test and Egger's test suggested that no publication bias of clinical pregnancy, ongoing pregnancy, live birth, miscarriage and ectopic pregnancy existed (all P>0.05), which indicated the stability of the present meta‑analysis. In conclusion, the oil‑based contrast medium enhances fertility outcomes compared with the water‑based contrast medium in patients receiving HSG.
View Figures
View References

Related Articles

Journal Cover

September-2023
Volume 26 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Liu S and Lu J: Comparison of fertility outcomes between oil‑based <br />and water‑based contrast media during hysterosalpingography: A meta‑analysis. Exp Ther Med 26: 449, 2023
APA
Chen, J., Liu, S., & Lu, J. (2023). Comparison of fertility outcomes between oil‑based <br />and water‑based contrast media during hysterosalpingography: A meta‑analysis. Experimental and Therapeutic Medicine, 26, 449. https://doi.org/10.3892/etm.2023.12148
MLA
Chen, J., Liu, S., Lu, J."Comparison of fertility outcomes between oil‑based <br />and water‑based contrast media during hysterosalpingography: A meta‑analysis". Experimental and Therapeutic Medicine 26.3 (2023): 449.
Chicago
Chen, J., Liu, S., Lu, J."Comparison of fertility outcomes between oil‑based <br />and water‑based contrast media during hysterosalpingography: A meta‑analysis". Experimental and Therapeutic Medicine 26, no. 3 (2023): 449. https://doi.org/10.3892/etm.2023.12148